Koo, Heebeom Huh, Myung Sook Ryu, Ju Hee Lee, Dong-Eun Sun, In-Cheol Choi, Kuiwon Kim, Kwangmeyung Kwon, Ick Chan 2024-01-20T17:30:20Z 2024-01-20T17:30:20Z 2021-09-02 2011-04 1748-0132 https://pubs.kist.re.kr/handle/201004/130489 Recent progress in bio and nanotechnology enables the development of various nanoprobes for biomedical imaging. The detection and imaging of specific changes in biological microenvironments play key roles in many fields such as biological mechanism study, drug screening, diagnosis of many diseases, and monitoring of therapeutic responses. Especially to obtain fine images in living systems, there are many requirements such as stability in complex condition, efficient accumulation in target site, and high sensitivity to the target molecule. For this purpose, many researchers have developed a number of nano-size probes sensitive to the external changes which are valuable from biomedical point of view. Herein, we will review the on-going challenges of developing novel nanoprobes to detect chemical or biological changes such as enzyme, oxygen, and pH, and applying them to biomedical imaging in living systems. (C) 2011 Elsevier Ltd. All rights reserved. English ELSEVIER SCI LTD IRON-OXIDE NANOPARTICLES PEPTIDE-BASED PROBES INDUCIBLE FACTOR-I TUMOR HYPOXIA DRUG-DELIVERY PHOTODYNAMIC THERAPY HYDROGEN-PEROXIDE INTRACELLULAR PH MULTIFUNCTIONAL NANOPARTICLES GOLD NANOPARTICLES Nanoprobes for biomedical imaging in living systems Article 10.1016/j.nantod.2011.02.007 1 NANO TODAY, v.6, no.2, pp.204 - 220 NANO TODAY 6 2 204 220 scie scopus 000290507200011 2-s2.0-79954414852 Chemistry, Multidisciplinary Nanoscience & Nanotechnology Materials Science, Multidisciplinary Chemistry Science & Technology - Other Topics Materials Science Review IRON-OXIDE NANOPARTICLES PEPTIDE-BASED PROBES INDUCIBLE FACTOR-I TUMOR HYPOXIA DRUG-DELIVERY PHOTODYNAMIC THERAPY HYDROGEN-PEROXIDE INTRACELLULAR PH MULTIFUNCTIONAL NANOPARTICLES GOLD NANOPARTICLES Nanoprobe Nanoparticle Imaging Diagnosis Sensor Nanotechnology