Tanaka, Ayano Arai, Yasuhiro Kim, Su-Nam Ham, Jungyeob Usuki, Toyonobu 2024-01-20T17:30:33Z 2024-01-20T17:30:33Z 2021-09-02 2011-04 1028-6020 https://pubs.kist.re.kr/handle/201004/130500 Concise total synthesis of bilobol 5-pentadecenylresorcinol (1), isolated from Gingko biloba fruits, has been achieved in 10 steps with 51% overall yield from 3,5-dihydroxybenzoic acid (3). Adipostatin A (2), isolated from the fruits as well as from Streptomyces cyaneus 2299-SV1, has also been synthesized in two steps from methylated bilobol (10). The structure-activity relationship study of synthetic products was described by means of cytotoxic assay against human KB carcinoma cell lines. English TAYLOR & FRANCIS LTD NATURALLY-OCCURRING 5-ALKYLRESORCINOLS LONG-CHAIN PHENOLS GINKGO-BILOBA DNA INHIBITORS Synthesis and biological evaluation of bilobol and adipostatin A Article 10.1080/10286020.2011.554828 1 JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, v.13, no.4, pp.290 - 296 JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 13 4 290 296 scie scopus 000289249300002 2-s2.0-79953698448 Plant Sciences Chemistry, Applied Chemistry, Medicinal Pharmacology & Pharmacy Plant Sciences Chemistry Pharmacology & Pharmacy Article NATURALLY-OCCURRING 5-ALKYLRESORCINOLS LONG-CHAIN PHENOLS GINKGO-BILOBA DNA INHIBITORS bilobol adipostatin A total synthesis cytotoxicity structure-activity relationship