Choi, Han-Saem Kim, Youn-Jung Song, Mee Song, Mi-Kyung Ryu, Jae-Chun 2024-01-20T17:30:39Z 2024-01-20T17:30:39Z 2021-09-02 2011-03-31 1738-642X https://pubs.kist.re.kr/handle/201004/130504 Toxaphene is a bioaccumulative, persistent, and toxic pollutant. Toxaphene is one of the 12 priority of Persistent Organic Pollutants (POPs) intended for global action by the United Nations Environment Program (UNEP) Governing Council. POPs are man-made synthetic chemicals highly resistant to biodegradation, with a high affinity for bioaccumulation (due to their hydrophobic and/or lipophilic nature) and biomagnification in the environment and living organisms, including humans. Once deposited in humans (mainly in adipose tissue), they form stable compounds that result in a lasting toxic body burden. Most human populations are exposed to mixtures of POPs originated either from local or remote sources. Toxaphene is ubiquitous in air, water, soil, and biological matrices, as well as in major environmental compartments. Toxaphene has effects on various organs such as thyroid, bone, skin, kidneys, and blood cells and especially, revealed strong toxicity to liver. In this study, we identified genes related to hepatotoxiciy induced by toxaphene in human hepatocellular carcinoma (HepG2) cells using microarray and gene ontology (GO) analysis. Through microarray analysis, we identified 1,647 up- and 2,251 down-regulated genes changed by more than 1.5-fold and P-values 0.001 by toxaphene. And after GO analysis, we determined several key pathways which known as related to hepatotoxicity such as MAPK signaling pathway, complement and coagulation cascades, tight junction. Thus, our present study suggests that genes expressed by toxaphene may provide a clue for hepatotoxic mechanism of toxaphene. English KOREAN SOCIETY TOXICOGENOMICS & TOXICOPROTEOMICS-KSTT ACTIVATABLE FIBRINOLYSIS INHIBITOR HEPATOCELLULAR-CARCINOMA EXPRESSION TOXICOLOGY PATTERNS Identification of hepatotoxicity related genes induced by toxaphene in HepG2 cells Article 10.1007/s13273-011-0008-y 1 MOLECULAR & CELLULAR TOXICOLOGY, v.7, no.1, pp.53 - 60 MOLECULAR & CELLULAR TOXICOLOGY 7 1 53 60 scie scopus kci other ART001543179 000289120400008 2-s2.0-79960103323 Biochemistry & Molecular Biology Toxicology Biochemistry & Molecular Biology Toxicology Article ACTIVATABLE FIBRINOLYSIS INHIBITOR HEPATOCELLULAR-CARCINOMA EXPRESSION TOXICOLOGY PATTERNS Persistent Organic Pollutants (POPs) Toxaphene Microarray Gene ontology (GO)