Thorat, Dhanaji Achyutrao Doddareddy, Munikumar Reddy Seo, Seon Hee Hong, Tae-Joon Cho, Yong Seo Hahn, Ji-Sook Pae, Ae Nim 2024-01-20T17:31:17Z 2024-01-20T17:31:17Z 2021-09-02 2011-03-15 0960-894X https://pubs.kist.re.kr/handle/201004/130536 Novel 2,4-diaminoquinazoline derivatives originating from a virtual screening approach were designed, synthesized and their biological activities as heat shock protein 90 (Hsp90) inhibitors were evaluated. The prepared compounds exhibited significant anti-proliferative activities against DU-145, HT-29, HCT-116, A375P and MCF-7 cancer cell lines. The selected compounds were tested against Her2, a client protein of Hsp90, and showed significant reduction in Her2 protein expression. Compound 6b was found the most potent, reduced Her2 protein expression levels and induced Hsp70 protein expression levels significantly. (C) 2011 Elsevier Ltd. All rights reserved. English Pergamon Press Ltd. NUCLEOTIDE-SEQUENCE THERAPEUTIC TARGET HSP90 CHAPERONE STRESS COMPLEX CDNA Synthesis and biological evaluation of 2,4-diaminoquinazoline derivatives as novel heat shock protein 90 inhibitors Article 10.1016/j.bmcl.2011.01.117 1 Bioorganic & Medicinal Chemistry Letters, v.21, no.6, pp.1593 - 1597 Bioorganic & Medicinal Chemistry Letters 21 6 1593 1597 scie scopus 000288012800004 2-s2.0-79952364637 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article NUCLEOTIDE-SEQUENCE THERAPEUTIC TARGET HSP90 CHAPERONE STRESS COMPLEX CDNA Hsp90 inhibitors Cancer 2,4-Diaminoquinazolines