Vulto, Paul Podszun, Susann Meyer, Philipp Hermann, Carsten Manz, Andreas Urban, Gerald A. 2024-01-20T17:31:31Z 2024-01-20T17:31:31Z 2022-01-25 2011-03 1473-0197 https://pubs.kist.re.kr/handle/201004/130547 Phaseguide technology gives complete control over filling and emptying of any type of microfluidic structures, independent of the chamber and channel geometry. The technique is based on a step-wise advancement of the liquid-air interface using the meniscus pinning effect. In this paper, the main effects and parameters underlying the phaseguiding principle are discussed and a demonstration is given of its potential for dead angle filling, spatially controlled phaseguide overflow and sequential phaseguide overflow, all accumulating in a passive valving approach. Phaseguides represent a new direction in microfluidic design thinking that will prove a leap forward towards more simple, flexible and reliable microfluidic systems. English Royal Society of Chemistry Phaseguides: a paradigm shift in microfluidic priming and emptying Article 10.1039/c0lc00643b 1 Lab on a Chip, v.11, no.9, pp.1596 - 1602 Lab on a Chip 11 9 1596 1602 N scie scopus 000289363800005 Biochemical Research Methods Chemistry, Multidisciplinary Chemistry, Analytical Nanoscience & Nanotechnology Instruments & Instrumentation Biochemistry & Molecular Biology Chemistry Science & Technology - Other Topics Instruments & Instrumentation Article LATEST DEVELOPMENTS ANALYSIS SYSTEMS MAMMALIAN-CELLS DEVICES PLATFORMS FLOW LAB