Jeong, Hayoung Huh, MyungSook Lee, So Jin Koo, Heebeom Kwon, Ick Chan Jeong, Seo Young Kim, Kwangmeyung 2024-01-20T17:31:56Z 2024-01-20T17:31:56Z 2021-09-05 2011-03 1838-7640 https://pubs.kist.re.kr/handle/201004/130568 Photodynamic therapy (PDT) is an emerging theranostic modality for various cancers and diseases. The focus of this study was the development of tumor-targeting albumin nanoparticles containing photosensitizers for efficient PDT. To produce tumor-targeting albumin nanoparticles, the hydrophobic photosensitizer, chlorin e6 (Ce6), was chemically conjugated to human serum albumin (HSA). The conjugates formed self-assembled nanoparticle structures with an average diameter of 88 nm under aqueous conditions. As expected, the Ce6-conjugated HSA nanoparticles (Ce6-HSA-NPs) were nontoxic in their native state, but upon illumination with the appropriate wavelength of light, they produced singlet oxygen and damaged target tumor cells in a cell culture system. Importantly, when the nanoparticles were injected through the tail vein into tumor-bearing HT-29 mice, Ce6-HSA-NPs compared with free Ce6 revealed enhanced tumor-specific biodistribution and successful therapeutic results following laser irradiation. These results suggest that highly tumor-specific albumin nanoparticles have the potential to serve not only as efficient therapeutic agents, but also as photodynamic imaging (PDI) reagents in cancer treatment. English IVYSPRING INT PUBL Photosensitizer-Conjugated Human Serum Albumin Nanoparticles for Effective Photodynamic Therapy Article 10.7150/thno/v01p0230 1 THERANOSTICS, v.1, pp.230 - 239 THERANOSTICS 1 230 239 N other 000299121000018 Medicine, Research & Experimental Research & Experimental Medicine Article CARRIERS DELIVERY CANCER Photodynamic therapy Human Serum Albumin Nanoparticles