Kim, Hanna Kim, Su-Nam Park, Yeon-Suk Kim, Nam Hyun Han, Jeung Whan Lee, Hoi Young Kim, Yong Kee 2024-01-20T17:32:36Z 2024-01-20T17:32:36Z 2021-09-02 2011-03 1019-6439 https://pubs.kist.re.kr/handle/201004/130602 Although histone deacetylase (HDAC) inhibitors are emerging as a promising class of cancer chemotherapeutic agents, their effects on multidrug resistance (MDR) are poorly understood. In this study, we investigated whether HDAC inhibitors overcome MDR phenotype. HDAC inhibitors suppress the growth of both MDR positive cancer cells KBV20C and its parental cells KB with similar potencies. In parallel, histone acetylation and p21(WAF1) expression by the HDAC inhibitors were similarly increased in both cell types, indicating that these HDAC inhibitors are poor substrates of ABC drug transporters and effective in MDR cancer cells. In addition, multidrug resistance protein 2 (MRP2) expression is selectively attenuated by HDAC inhibitors, especially SAHA and TSA, in KBV20C cells, whereas MDR1 and BCRP expressions are not affected. This downregulation of MRP2 contributes to increase in paclitaxel-induced G(2)/M arrest and apoptosis, which might be due to intracellular accumulation of paclitaxel. Collectively, our data provide a molecular rationale for the application of HDAC inhibitors to overcome MDR in cancer cells. English SPANDIDOS PUBL LTD HISTONE DEACETYLASE INHIBITOR SUBEROYLANILIDE HYDROXAMIC ACID PROMYELOCYTIC LEUKEMIA-CELLS P-GLYCOPROTEIN PHASE-I DEPSIPEPTIDE FR901228 DRUG-RESISTANCE PROMOTER REGION APICIDIN INDUCTION HDAC inhibitors downregulate MRP2 expression in multidrug resistant cancer cells: Implication for chemosensitization Article 10.3892/ijo.2010.879 1 INTERNATIONAL JOURNAL OF ONCOLOGY, v.38, no.3, pp.807 - 812 INTERNATIONAL JOURNAL OF ONCOLOGY 38 3 807 812 scie scopus 000287829200023 2-s2.0-79952029403 Oncology Oncology Article HISTONE DEACETYLASE INHIBITOR SUBEROYLANILIDE HYDROXAMIC ACID PROMYELOCYTIC LEUKEMIA-CELLS P-GLYCOPROTEIN PHASE-I DEPSIPEPTIDE FR901228 DRUG-RESISTANCE PROMOTER REGION APICIDIN INDUCTION HDAC inhibitor multidrug resistance MRP2