Choi, Kee-Hyun Song, Chiman Cheong, Chan S. Rhim, Hyewhon 2024-01-20T17:32:55Z 2024-01-20T17:32:55Z 2021-09-02 2011-03 0231-5882 https://pubs.kist.re.kr/handle/201004/130618 T-type calcium channels are involved in a variety of physiological and pathophysiological processes, and thus could be therapeutic targets. However, there is no T-type channel selective blocker for use in clinical practice, demanding a need for the development of novel drugs where a higher-throughput screening system is required. Here we present pharmacological studies on Ca(v)3.1 T-type channels using automated patch-clamp. The IC50 values obtained from automated patch-clamp and conventional one showed a good correlation (correlation coefficient of 0.82), suggesting that the automated patch-clamp is an efficient and reliable method for ranking the drug potencies for T-type channels. English GENERAL PHYSIOL AND BIOPHYSICS THROUGHPUT ELECTROPHYSIOLOGY BLOCK INHIBITION VERAPAMIL RECEPTOR NEURONS Pharmacological studies of Ca(v)3.1 T-type calcium channels using automated patch-clamp techniques Article 10.4149/gpb_2011_01_100 1 GENERAL PHYSIOLOGY AND BIOPHYSICS, v.30, no.1, pp.100 - 105 GENERAL PHYSIOLOGY AND BIOPHYSICS 30 1 100 105 scie scopus 000288888600013 2-s2.0-79953716794 Biochemistry & Molecular Biology Biophysics Physiology Biochemistry & Molecular Biology Biophysics Physiology Article THROUGHPUT ELECTROPHYSIOLOGY BLOCK INHIBITION VERAPAMIL RECEPTOR NEURONS T-Type calcium channel Ca(v)3.1 Automated patch-clamp Drug discovery