Cheong, Eunji Kim, Chanki Choi, B. Jiwon Sun, Minjeong Shin, Hee-Sup 2024-01-20T17:35:01Z 2024-01-20T17:35:01Z 2021-09-02 2011-01-26 0270-6474 https://pubs.kist.re.kr/handle/201004/130718 Ryanodine receptors (RyRs) are highly conductive intracellular Ca(2+) release channels which are widely expressed in the CNS. They rapidly increase the intracellular Ca(2+) concentrations in neuronal cells in response to Ca(2+) influx through voltage-gated Ca(2+) channels. A previous study reported that RyRs were expressed in thalamocortical (TC) neurons, but their physiological function has remained elusive. Here, we show that the activation of RyRs in TC neurons in mice decreases their tonic firing rate while blocking them induces the opposite response. Furthermore, activation of RyRs in ventroposteriomedial/ventroposteriolateral nuclei reduces the behavioral responses to inflammatory pain and blocking them increases the responses. This study highlights the importance of the intracellular Ca(2+) release via RyRs in controlling the excitability of TC neurons and in inflammatory pain signal processing in the thalamus. English SOC NEUROSCIENCE CA2+ CHANNELS NOCICEPTION MICE Thalamic Ryanodine Receptors Are Involved in Controlling the Tonic Firing of Thalamocortical Neurons and Inflammatory Pain Signal Processing Article 10.1523/JNEUROSCI.3203-10.2011 1 JOURNAL OF NEUROSCIENCE, v.31, no.4, pp.1213 - 1218 JOURNAL OF NEUROSCIENCE 31 4 1213 1218 scie scopus 000286655600007 2-s2.0-79251553117 Neurosciences Neurosciences & Neurology Article CA2+ CHANNELS NOCICEPTION MICE Thalamus ryanodine receptor inflammatory pain calcium