Lim, Chang-Keun Shin, Jiyoung Lee, Yong-Deok Kim, Jungahn Park, Hoyong Kwon, Ick Chan Kim, Sehoon 2024-01-20T18:00:29Z 2024-01-20T18:00:29Z 2021-09-02 2011-01-03 1613-6810 https://pubs.kist.re.kr/handle/201004/130735 A new type of heavy-atom-affected Pluronic (F-127) nanoparticle (FIC NP) for photodynamic therapy (PDT) is reported. FIC NPs are formulated with biocompatible constituents, and contain densely integrated iodinated aromatic molecules that form a structurally rigid core matrix and stably encapsulate photosensitizers in a monomeric form. Tiny nanoparticles (approximate to 10 nm) are prepared by aqueous dispersion of photosensitizer-embedded aromatic nanodomains, which self-assemble by phase separation from the Pluronic melt mixture. By using spectroscopic studies and cellular experiments, the following is demonstrated: 1) enhanced singlet-oxygen generation by means of the intraparticle heavy-atom effect on the embedded photosensitizer, 2) facilitated cell uptake due to the small nanoscopic size as well as the Pluronic surface characteristics, and thereby 3) actual enhancement of PDT efficacy for a human breast-cancer cell line (MDA-MB-231), which validates a photophysically motivated nanoformulation approach toward an advanced photosensitizing nanomedicine. English WILEY-V C H VERLAG GMBH MODIFIED SILICA NANOPARTICLES SINGLET OXYGEN DELIVERY PORPHYRIN APOPTOSIS ASSAY Heavy-Atomic Construction of Photosensitizer Nanoparticles for Enhanced Photodynamic Therapy of Cancer Article 10.1002/smll.201001358 1 SMALL, v.7, no.1, pp.112 - 118 SMALL 7 1 112 118 scie scopus 000285794100013 2-s2.0-78650782020 Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Physics, Condensed Matter Chemistry Science & Technology - Other Topics Materials Science Physics Article MODIFIED SILICA NANOPARTICLES SINGLET OXYGEN DELIVERY PORPHYRIN APOPTOSIS ASSAY nanoparticles photodynamic therapy Pluronic self-assembly singlet oxygen