Lee, Jeong Yong Jung, Hyun Wook Hyun, Jae Chun Chun, Myung-Suk 2024-01-20T18:01:04Z 2024-01-20T18:01:04Z 2021-09-05 2011-01 0374-4884 https://pubs.kist.re.kr/handle/201004/130762 The migration and conformation of a single lambda-DNA chain in a microchannel with a 90 degrees bend have been investigated using the hybrid numerical scheme of Brownian dynamics (BD) simulations and a CFD (computational fluid dynamics) solver, Flow-3D. A significant displacement of the single DNA chain was found after it had passed through the microbend and depended on its initial location. The lambda-DNA chain initially positioned near the inner (or outer) wall migrated farther toward the inner (or outer) wall after passage through the bend. This is ascribed by the hydrodynamic features of the bulk flow field in the bend region. The relationship between an extension of the single chain and the flow characteristics was elucidated by changing the effective shear rate and the channel width. English KOREAN PHYSICAL SOC FLEXIBLE POLYMERS MULTISCALE SIMULATION BROWNIAN DYNAMICS DILUTE-SOLUTIONS MOLECULE Lateral Displacement and Conformation of DNA Chains in Abrupt 90 degrees Microbends Article 10.3938/jkps.58.125 1 JOURNAL OF THE KOREAN PHYSICAL SOCIETY, v.58, no.1, pp.125 - 131 JOURNAL OF THE KOREAN PHYSICAL SOCIETY 58 1 125 131 scie scopus kci ART001520318 000288414300025 2-s2.0-78751506086 Physics, Multidisciplinary Physics Article FLEXIBLE POLYMERS MULTISCALE SIMULATION BROWNIAN DYNAMICS DILUTE-SOLUTIONS MOLECULE lambda-DNA molecule Brownian dynamics Microbends Migration Conformation