El-Gamal, Mohammed I. Oh, Chang-Hyun 2024-01-20T18:02:57Z 2024-01-20T18:02:57Z 2022-01-10 2010-12 1568-0266 https://pubs.kist.re.kr/handle/201004/130847 beta-Lactam antibiotics are the most prescribed antibacterial agents. They comprise more than half of all antibiotics. They are considered as the cornerstone of the antibiotic armamentarium. By inhibiting bacterial cell wall biosynthesis, they are highly effective against Gram-positive and Gram-negative bacteria. Antibiotic resistance among Gram-negative pathogens in hospitals represents a dangerous threat to public health. Since many bacteria have developed resistance to older agents, new beta-lactam antibiotics have been continuously developed. In the late 1970s, a new class of exceptionally broad-spectrum non-traditional beta-lactams, carbapenems, was developed. This review article focuses on the new developments related to the field of carbapenems for treatment of bacterial infections, especially those caused by Gram-negative bacteria. The structural features, principal characteristics, and clinical implications of carbapenems including thienamycin, imipenem/cilastatin, panipenem/betamipron, biapenem, tebipenem, tebipenem pivoxil, meropenem, ertapenem, doripenem, lenapenem, and tomopenem are discussed herein. English BENTHAM SCIENCE PUBL LTD IN-VITRO ACTIVITY VIVO ANTIBACTERIAL ACTIVITIES GRAM-NEGATIVE BACILLI INTENSIVE-CARE UNITS PSEUDOMONAS-AERUGINOSA BETA-LACTAMASE PARENTERAL CARBAPENEM NOSOCOMIAL INFECTIONS CS-023 RO4908463 DORIPENEM S-4661 Current Status of Carbapenem Antibiotics Article 1 CURRENT TOPICS IN MEDICINAL CHEMISTRY, v.10, no.18, pp.1882 - 1897 CURRENT TOPICS IN MEDICINAL CHEMISTRY 10 18 1882 1897 scie scopus 000285185000005 2-s2.0-78649946454 Chemistry, Medicinal Pharmacology & Pharmacy Review IN-VITRO ACTIVITY VIVO ANTIBACTERIAL ACTIVITIES GRAM-NEGATIVE BACILLI INTENSIVE-CARE UNITS PSEUDOMONAS-AERUGINOSA BETA-LACTAMASE PARENTERAL CARBAPENEM NOSOCOMIAL INFECTIONS CS-023 RO4908463 DORIPENEM S-4661 Carbapenems beta-lactams beta-lactamases carbapenemases nosocomial infections community-acquired infections multidrug resistance polymicrobial infections