Yi, Dong Kee Sun, In-Cheol Ryu, Ju Hee Koo, Heebeom Park, Chul Wan Youn, In-Chan Choi, Kuiwon Kwon, Ick Chan Kim, Kwangmeyung Ahn, Cheol-Hee 2024-01-20T18:03:09Z 2024-01-20T18:03:09Z 2021-09-05 2010-12 1043-1802 https://pubs.kist.re.kr/handle/201004/130858 Herein, we developed matrix metalloprotease (MMP) sensitive gold nanorods (MMP-AuNR) for cancer imaging and therapy. It was feasible to absorb NIR laser and convert into heat as well as visualize MMP activity. We showed the possibility of gold nanorods as a hyperthermal therapeutic agent and MMP sensitive imaging agent both in vitro and in vivo condition. The results suggested potential application of MMP-AuNR for simultaneous cancer diagnosis and therapy. English AMER CHEMICAL SOC DRUG-DELIVERY NANOPARTICLES PPTT Matrix Metalloproteinase Sensitive Gold Nanorod for Simultaneous Bioimaging and Photothermal Therapy of Cancer Article 10.1021/bc100308p 1 BIOCONJUGATE CHEMISTRY, v.21, no.12, pp.2173 - 2177 BIOCONJUGATE CHEMISTRY 21 12 2173 2177 scie scopus 000285236300004 2-s2.0-78650336753 Biochemical Research Methods Biochemistry & Molecular Biology Chemistry, Multidisciplinary Chemistry, Organic Biochemistry & Molecular Biology Chemistry Article DRUG-DELIVERY NANOPARTICLES PPTT gold nanorod matrix metalloprotease MMP Theragnosis photothermal therapy bioimaging