Chang, Rae Sung Kim, Jiyeon Lee, Han Young Han, Su-Eun Na, Jinhee Kim, Kwangmeyung Kwon, Ick Chan Kim, Young Bong Oh, Yu-Kyoung 2024-01-20T18:03:55Z 2024-01-20T18:03:55Z 2021-09-04 2010-12 1549-9634 https://pubs.kist.re.kr/handle/201004/130896 Intraperitoneal chemotherapy confers limited clinical benefit as a result of the dose-limiting toxicity of anticancer drugs. We aimed to develop optimized liposomes for mitoxantrone (MTO) administration that provide high encapsulation efficiency and increase the therapeutic index. Cationic MTO was loaded onto anionic liposomes by electrostatic surface complexation. The anticancer activity was evaluated in a peritoneal carcinomatosis model. The retention of MTO at the tumor site was monitored by molecular imaging. MTO loading efficiencies by electrostatic complexation were >95% for all anionic liposomes but <5% for neutral liposomes. Among anionic liposomes, cardiolipin liposomes (CLs) exhibited the strongest binding affinity for MTO, the highest anticancer activity, and the lowest toxicity. MTO delivered by CLs showed prolonged retention at tumor sites. Unlike free MTO showing significant cardiotoxicity, MTO administered in CLs provided negligible cardiotoxicity. CL-mediated delivery may increase the therapeutic index of MTO chemotherapy by prolonged retention and reduced cardiotoxicity. From the Clinical Editor: The authors report the development of optimized liposomes for intraperitoneal mitoxantrone delivery that provides high encapsulation efficiency and increases the therapeutic index. Cardiolipin liposomes exhibited the strongest binding affinity for mitoxantrone, along with the highest anti-cancer activity and lowest toxicity, including negligible cardiotoxicity. (C) 2010 Elsevier Inc. All rights reserved. English ELSEVIER SCIENCE BV PERITONEAL CARCINOMATOSIS IN-VITRO CYTOREDUCTIVE SURGERY COLORECTAL-CANCER DNA DELIVERY EFFICACY ENCAPSULATION MANAGEMENT MORBIDITY COMPLEX Reduced dose-limiting toxicity of intraperitoneal mitoxantrone chemotherapy using cardiolipin-based anionic liposomes Article 10.1016/j.nano.2010.05.003 1 NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, v.6, no.6, pp.769 - 776 NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 6 6 769 776 scie scopus 000284943200008 2-s2.0-78649845506 Nanoscience & Nanotechnology Medicine, Research & Experimental Science & Technology - Other Topics Research & Experimental Medicine Article PERITONEAL CARCINOMATOSIS IN-VITRO CYTOREDUCTIVE SURGERY COLORECTAL-CANCER DNA DELIVERY EFFICACY ENCAPSULATION MANAGEMENT MORBIDITY COMPLEX Intraperitoneal chemotherapy Mitoxanthrone Cardiolipin liposomes Dose-limiting toxicity Prolonged retention