Moon, Byung Seok Jo, Nam Hyun Lee, Kyo Chul Ei-Gamal, Mohammed I. An, Gwang Il Hong, Su Hee Choi, Tae Hyun Choi, Won-Kyoung Park, Jin-Hun Cho, Jung-Hyuck Cheon, Gi Jeong Oh, Chang-Hyun 2024-01-20T18:04:17Z 2024-01-20T18:04:17Z 2022-01-10 2010-11-20 0253-2964 https://pubs.kist.re.kr/handle/201004/130911 D-[(18) F]FMAU and L-[F-18]FMAU are F-18 labeled nucleoside analogue which have been efficiently synthesized in order to be a PET imaging probe D-[F-18]FMAU and L-[F-18]FMAU were compared as PET imaging agents using HSV1-TK gene expressing tumor-bearing mice Their cellular uptake profiles were also compared using MCA and MCA-TK cell lines D-[F-18]FMAU demonstrated higher cellular uptake and higher accumulation in MCA-TK tumor regions than L-[F-18]FMAU On the other hand, L-[F-18]FMAU showed higher MCA-TK/MCA ratio of %ID/g than that of D-[F-18]FMAU L-[F-18]FMAU can be utilized as a good candidate for HSV1-TK PET imaging It can be used for antiviral drug evaluation English KOREAN CHEMICAL SOC VIRUS THYMIDINE KINASE IN-VIVO DNA-SYNTHESIS FIALURIDINE CARCINOMA THERAPY FIAU Comparison of D-[F-18]FMAU and L-[F-18]FMAU as PET Imaging Agents for HSV1-TK Gene Expression Article 10.5012/bkcs.2010.31.11.3309 1 BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.31, no.11, pp.3309 - 3312 BULLETIN OF THE KOREAN CHEMICAL SOCIETY 31 11 3309 3312 scie scopus kci ART001526263 000284794100047 2-s2.0-78549282060 Chemistry, Multidisciplinary Chemistry Article VIRUS THYMIDINE KINASE IN-VIVO DNA-SYNTHESIS FIALURIDINE CARCINOMA THERAPY FIAU HSV1-TK D-[F-18]FMAU L-[F-18]FMAU PET imaging MicroPET