Kim, Dae Hyun Im, Jin Kyu Kim, Dae Won Lee, Hyunjoo Kim, Honggan Kim, Hoon Sik Cheong, Minserk Mukherjee, Deb Kumar 2024-01-20T18:04:53Z 2024-01-20T18:04:53Z 2021-09-05 2010-11 0340-4285 https://pubs.kist.re.kr/handle/201004/130938 The asymmetric C-alkylation of benzophenone Schiff base glycine esters has been achieved using a palladium(II) chiral complex as a phase-transfer catalyst. The aromatic moiety around the metal center and various physicochemical parameters were investigated to study their effect on the asymmetric alkylation reaction under phase-transfer conditions. Moderate enantioselectivity(30-40%) was achieved under room temperature conditions, which is a significant improvement compared to no enantioselectivity with a chiral palladium-salen complex reported earlier. Computer simulation studies indicate that coordination of the metal center with Z-enolate forming a square planar complex provides a favorable steric environment where the alpha-carbon atom of the enolate is available for enantioselective alkylation. English SPRINGER ALPHA-AMINO-ACIDS ENANTIOSELECTIVE SYNTHESIS AMMONIUM-SALTS IMMOBILIZATION DIASTEREOMERS DERIVATIVES DIMERS ROUTE Orthopalladated complexes as phase-transfer catalysts for asymmetric alkylation of achiral Schiff base esters Article 10.1007/s11243-010-9416-4 1 TRANSITION METAL CHEMISTRY, v.35, no.8, pp.949 - 957 TRANSITION METAL CHEMISTRY 35 8 949 957 scie scopus 000283240500007 2-s2.0-78149471438 Chemistry, Inorganic & Nuclear Chemistry Article ALPHA-AMINO-ACIDS ENANTIOSELECTIVE SYNTHESIS AMMONIUM-SALTS IMMOBILIZATION DIASTEREOMERS DERIVATIVES DIMERS ROUTE