Lee, Hyun Ju Choi, Chang Won Kim, Beyong Il Kim, Ee-Kyung Kim, Han-Suk Choi, Jung-Hwan Lee, Myong Jin Yang, Eun Gyeong 2024-01-20T18:30:40Z 2024-01-20T18:30:40Z 2021-09-04 2010-11 0300-5577 https://pubs.kist.re.kr/handle/201004/130980 Aim: To investigate serial changes of lung morphology and biochemical profiles in a rat model of bronchopulmonary dysplasia (BPD) induced by intra-amniotic lipopolysaccharide (LPS) administration and postnatal hyperoxia (85%). Methods: We evaluated histological changes of the lungs and compared the levels of interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), and protein carbonyl in lung tissue on days 1, 7, and 14 after birth in a rat model of BPD. Results: The inhibition of alveolarization was sustained in the LPS plus hyperoxia group from day 7 to 14, whereas alveolarization resumed in the hyperoxia group after oxygen exposure was withdrawn at day 7. Administration of LPS alone did not adversely affect lung morphometry. IL-6 levels showed transient overexpression at day 1 in the LPS-treated groups, but decreased at days 7 and 14. VEGF protein levels were elevated in the LPS-treated groups, but not in the hyperoxia and control groups at days 1, 7, and 14. Exposure to hyperoxia affected protein carbonyl levels in the hyperoxia group at days 7 and 14. Conclusion: Lung injury induced by intra-amniotic inflammation and postnatal hyperoxia may be due to inhibition of alveolarization without recovery even after withdrawal of oxygen. English WALTER DE GRUYTER GMBH ANTENATAL ENDOTOXIN OXIDATIVE STRESS PRETERM INFANTS INFLAMMATION INJURY CHORIOAMNIONITIS ANGIOGENESIS INVOLVEMENT EXPRESSION DISEASE Serial changes of lung morphology and biochemical profiles in a rat model of bronchopulmonary dysplasia induced by intra-amniotic lipopolysaccharide and postnatal hyperoxia Article 10.1515/JPM.2010.091 1 JOURNAL OF PERINATAL MEDICINE, v.38, no.6, pp.675 - 681 JOURNAL OF PERINATAL MEDICINE 38 6 675 681 scie scopus 000284102500016 2-s2.0-78650134529 Obstetrics & Gynecology Pediatrics Obstetrics & Gynecology Pediatrics Article ANTENATAL ENDOTOXIN OXIDATIVE STRESS PRETERM INFANTS INFLAMMATION INJURY CHORIOAMNIONITIS ANGIOGENESIS INVOLVEMENT EXPRESSION DISEASE Bronchopulmonary dysplasia chorioamnionitis interleukin-6 protein carbonyl vascular endothelial growth factor