Oh, Chang Hyun Liu, Lian Jin Hong, Joon Hee 2024-01-20T18:32:34Z 2024-01-20T18:32:34Z 2021-09-05 2010-10 1525-7770 https://pubs.kist.re.kr/handle/201004/131072 A novel 3',4'-dimethyl-5'-norcarbocyclic adenosine phosphonic acid was prepared using acyclic stereoselective route from 4-hydroxybutan-2-one (4). To improve the cellular permeability and enhance the anti-HIV activity of this phosphonic acid, a (bis)SATE phosphonodiester nucleoside prodrug (20) was prepared and its chemical stability was evaluated. The newly synthesized bis(SATE) analogue (20) and its parent nucleoside phosphonic acid (18) were assayed for anti-HIV activity using an in vitro assay system in a CEM cell line. English TAYLOR & FRANCIS INC HCMV ACTIVITY NUCLEOSIDES METABOLISM DELIVERY AGENTS Design and Synthesis of Dually Branched 5'-Norcarbocyclic Adenosine Phosphonodiester Analogue as a New Anti-HIV Prodrug Article 10.1080/15257770.2010.509645 1 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, v.29, no.10, pp.721 - 733 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 29 10 721 733 scie scopus 000282581000001 2-s2.0-77957979311 Biochemistry & Molecular Biology Biochemistry & Molecular Biology Article HCMV ACTIVITY NUCLEOSIDES METABOLISM DELIVERY AGENTS Anti-HIV agent bis(SATE) derivative nucleoside adenine phosphonic acid