Lee, Yong-Deok Lim, Chang-Keun Kim, Sehoon Kwon, Ick Chan Kim, Jungahn 2024-01-20T18:33:24Z 2024-01-20T18:33:24Z 2021-09-05 2010-09-09 1616-301X https://pubs.kist.re.kr/handle/201004/131108 Hydrophobically stabilized near-IR fluorescence from self-assembled nanoprobes composed of amphiphilic poly(maleic anhydride-alt-octadec-1-ene) (PMAO) and lipophilized squaraine dopants is reported. From comparative studies with varying lipophilicity of squaraine dyes as well as of nanoparticulate polymer matrices, it is found that dual protection by simultaneous lipophilization of the dye-polymer pair greatly improves the chemical stability of labile squaraine dyes, to produce efficient NIR fluorescence in physiological aqueous milieux. The surface properties of negatively charged PMAO nanoparticles are readily modified by coating with an amine-rich cationic glycol chitosan with biofunctionality. Efficient cellular imaging and in vivo sentinel lymph node mapping with size and surface-controlled nanoprobes demonstrate that lipophilic dual protection of NIR fluorescence and the underlying functional nanoprobe approach hold great potential for bioimaging applications. English WILEY-BLACKWELL IR DYES NANOPARTICLES NANOCRYSTALS ROTAXANES ENCAPSULATION CHEMISTRY SYSTEMS PROBES DRUGS Squaraine-Doped Functional Nanoprobes: Lipophilically Protected Near-Infrared Fluorescence for Bioimaging Article 10.1002/adfm.201000650 1 ADVANCED FUNCTIONAL MATERIALS, v.20, no.17, pp.2786 - 2793 ADVANCED FUNCTIONAL MATERIALS 20 17 2786 2793 scie scopus 000282288600004 2-s2.0-77956920963 Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Physics, Condensed Matter Chemistry Science & Technology - Other Topics Materials Science Physics Article IR DYES NANOPARTICLES NANOCRYSTALS ROTAXANES ENCAPSULATION CHEMISTRY SYSTEMS PROBES DRUGS bioimaging biomedical applications near-infrared fluorescence polymer nanoparticles self-assembly