최동훈 유승권 김익환 한동근 박귀덕 2024-01-20T18:33:47Z 2024-01-20T18:33:47Z 2021-09-06 2010-09 1226-4601 https://pubs.kist.re.kr/handle/201004/131124 Due to their enormous therapeutic potential, induced pluripotent stem (iPS) cells have emerged as the most promising source for cell-based applications in regenerative medicine. In this study, iPS cells were subject to chondrogenic and osteogenic differentiation in vitro using either fibrin gel or biodegradable poly(lactic-co-glycolic) acid (PLGA) and gelatin. As an adult stem cell, adipose-derived stem cells (ASCs) were also tested. While the iPS cells could form a colony only on the substrate of PLGA/gelatin film, ASCs were spreading and growing well on the PLGA itself as well as on the film. The cell growth rate of iPS cells was rather fast on the gelatin-coated plate. The gene expression levels of chondrogenic or osteogenic markers were notable with iPS cells, which were comparable with those of ASCs. This study indicates that iPS cells can be another useful cell source in musculoskeletal tissue engineering Korean 한국생체재료학회 조직공학적 응용을 위한 역분화 줄기세포의 연골 및 골 분화 유도 Induction of Chondrogenic or Osteogenic Differentiation Using Induced Pluripotent Stem (iPS) Cells for Tissue Engineering Applications Article 2 생체재료학회지, v.14, no.3, pp.118 - 123 생체재료학회지 14 3 118 123 kci ART001476456 Tissue engineering iPS cells differentiation chondrogenesis osteogenesis PLGA gelatin