Cho, Young-Chang Lee, Sung Ho Yoon, Goo Kim, Hyung-Seok Na, Joo Young Choi, Hyun Jin Cho, Cheng-Weon Cheon, Seung Hoon Kang, Bok Yun 2024-01-20T18:34:01Z 2024-01-20T18:34:01Z 2021-09-05 2010-09 1567-5769 https://pubs.kist.re.kr/handle/201004/131136 Licochalcone, a constituent of licorice, has antitumor, antimicrobial, and anti-inflammatory effects. Recently, licochalcone E was isolated from the roots of Glycyrrhiza inflata and its biological functions are not fully examined. In this study, we investigated its ability to modulate production of IL-12p40, a common subunit of IL-12 and IL-23. Licochalcone E dose-dependently inhibited IL-12p40 production from lipopolysaccharide-stimulated RAW264.7 macrophage cells. The repressive effect was mapped to a region in the IL-12 gene promoter containing a binding site for NF-kappa B. Furthermore, licochalcone E decreased binding to the NF-kappa B site in RAW264.7 macrophage cells. Using a chronic allergic contact dermatitis model induced by repeated application of oxazolone, we showed that licochalcone E inhibited the increased IL-12p40 expression and ear thickness induced by oxazolone. Taken together, licochalcone E inhibits IL-12p40 production and has therapeutic potential to reduce skin inflammation. (C) 2010 Elsevier B.V. All rights reserved. English ELSEVIER SCIENCE BV GLYCYRRHIZA-INFLATA T-CELLS PARASITE MITOCHONDRIA PSORIASIS-VULGARIS INTERFERON-GAMMA INTERLEUKIN-12 CYTOKINE IL-23 P40 EXPRESSION Licochalcone E reduces chronic allergic contact dermatitis and inhibits IL-12p40 production through down-regulation of NF-kappa B Article 10.1016/j.intimp.2010.06.015 1 INTERNATIONAL IMMUNOPHARMACOLOGY, v.10, no.9, pp.1119 - 1126 INTERNATIONAL IMMUNOPHARMACOLOGY 10 9 1119 1126 scie scopus 000281981600018 2-s2.0-77955920339 Immunology Pharmacology & Pharmacy Immunology Pharmacology & Pharmacy Article GLYCYRRHIZA-INFLATA T-CELLS PARASITE MITOCHONDRIA PSORIASIS-VULGARIS INTERFERON-GAMMA INTERLEUKIN-12 CYTOKINE IL-23 P40 EXPRESSION Licochalcone E Inteleukin-12p40 NF-kappa B Allergic contact dermatitis