Choi, Jee Hyun Koch, Klaus Peter Poppendieck, Wigand Lee, Mina Shin, Hee-Sup 2024-01-20T18:34:08Z 2024-01-20T18:34:08Z 2021-09-05 2010-09 0022-3077 https://pubs.kist.re.kr/handle/201004/131141 Choi JH, Koch KP, Poppendieck W, Lee M, Shin HS. High resolution electroencephalography in freely moving mice. J Neurophysiol 104: 1825-1834, 2010. First published July 7, 2010; doi: 10.1152/jn.00188.2010. Electroencephalography (EEG) is a standard tool for monitoring brain states in humans. Understanding the molecular and cellular mechanisms underlying diverse EEG rhythms can be facilitated by using mouse models under molecular, pharmacological, or electrophysiological manipulations. The small size of the mouse brain, however, poses a severe limitation in the spatial information of EEG. To overcome this limitation, we devised a polyimide based microelectrode array (PBM array) with nanofabrication technologies. The microelectrode contains 32 electrodes, weighs 150 mg, and yields noise-insensitive signals when applied on the mouse skull. The high-density microelectrode allowed both global and focused mapping of high resolution EEG (HR-EEG) in the mouse brain. Mapping and dynamical analysis tools also have been developed to visualize the dynamical changes of spatially resolved mouse EEG. We demonstrated the validity and utility of mouse EEG in localization of the seizure onset in absence seizure model and phase dynamics of abnormal theta rhythm in transgenic mice. Dynamic tracking of the EEG map in genetically modified mice under freely moving conditions should allow study of the molecular and cellular mechanisms underlying the generation and dynamics of diverse EEG rhythms. English AMER PHYSIOLOGICAL SOC ABSENCE SEIZURES PHASE SYNCHRONIZATION THETA OSCILLATIONS GAMMA OSCILLATIONS ELECTRODE ARRAYS EEG POLYIMIDE NEURONS RHYTHM NETWORKS High Resolution Electroencephalography in Freely Moving Mice Article 10.1152/jn.00188.2010 1 JOURNAL OF NEUROPHYSIOLOGY, v.104, no.3, pp.1825 - 1834 JOURNAL OF NEUROPHYSIOLOGY 104 3 1825 1834 scie scopus 000281910600056 2-s2.0-77957201512 Neurosciences Physiology Neurosciences & Neurology Physiology Article ABSENCE SEIZURES PHASE SYNCHRONIZATION THETA OSCILLATIONS GAMMA OSCILLATIONS ELECTRODE ARRAYS EEG POLYIMIDE NEURONS RHYTHM NETWORKS 뇌파 박막전극 Electroencephalography (EEG) Mouse Topography Nanofabrication