Lee, W. Kim, S.-N. Yoon, G. 2024-01-20T18:34:27Z 2024-01-20T18:34:27Z 2021-09-02 2010-09 0253-3073 https://pubs.kist.re.kr/handle/201004/131158 Protein tyrosine phosphatase 1B (PTP1B) is predicted to be therapeutic target in treatment of type 2 diabetes and obesity. Thus, in order to search for PTP1B inhibitors, we screened the inhibitory activity of PTP1B in the water extracts of 84 medicinal herbs. Among them, the extracts of Pini Folium, Magnoliae Cortex, Artemisiae asiaticae Herba, Schizonepetae Herba, Menthae Herba, Mume Fructus, Cimicifugae Rhizoma, and Amomi Cardamomi Fructus showed relatively significant (58-68%) inhibitory activity against PTP1B. Especially, the methylene chloride fraction of the methanol extract of Menthae Herba (81% inhibition at 30 μg/ml) showed more potent inhibitory activity against PTP1B than others. Korean Amomi cardamomi fructus extract Artemisiae asiaticae herba extract Cimicifugae rhizoma extract dichloromethane Magnoliae cortex extract Menthae herba extract Mume fructus extract Pini folium extract plant extract protein tyrosine phosphatase 1B Schizonepetae herba extract unclassified drug Amomi cardamomi fructus Artemisiae asiaticae herba article Cimicifugae rhizoma drug activity drug screening enzyme inhibition Magnoliae cortex medicinal plant Menthae herba Mume fructus Pini folium Schizonepetae herba Screening of medicinal herbs for inhibitory activity against protein tyrosine phosphatase 1B Article 1 Korean Journal of Pharmacognosy, v.41, no.3, pp.227 - 231 Korean Journal of Pharmacognosy 41 3 227 231 scopus kci ART001485202 2-s2.0-79952378318 Article Amomi cardamomi fructus extract Artemisiae asiaticae herba extract Cimicifugae rhizoma extract dichloromethane Magnoliae cortex extract Menthae herba extract Mume fructus extract Pini folium extract plant extract protein tyrosine phosphatase 1B Schizonepetae herba extract unclassified drug Amomi cardamomi fructus Artemisiae asiaticae herba article Cimicifugae rhizoma drug activity drug screening enzyme inhibition Magnoliae cortex medicinal plant Menthae herba Mume fructus Pini folium Schizonepetae herba Medicinal herb Menthae herba Obesity Protein tyrosine phosphatase 1B Type 2 diabetes