Kam, Yoo Lim Rhee, Hee-Kyung Rhim, Hyewhon Back, Seung Keun Na, Heung Sik Choo, Hea-Young Park 2024-01-20T18:34:47Z 2024-01-20T18:34:47Z 2021-09-05 2010-08-15 0968-0896 https://pubs.kist.re.kr/handle/201004/131173 Novel diphenylpiperazine derivatives were synthesized and evaluated for their inhibitory activity against T-type calcium channel by whole-cell patch clamp recordings on HEK293 cells. Among the test compounds, 2 and 3d were effective in decreasing the response to formalin in both the first and second phases and demonstrated antiallodynic effects in a rat model of neuropathic pain. (C) 2010 Elsevier Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD CA2+ CHANNELS PAIN RAT MIBEFRADIL ALLODYNIA BLOCKERS MODEL Synthesis and T-type calcium channel blocking activity of novel diphenylpiperazine compounds, and evaluation of in vivo analgesic activity Article 10.1016/j.bmc.2010.06.082 1 BIOORGANIC & MEDICINAL CHEMISTRY, v.18, no.16, pp.5938 - 5944 BIOORGANIC & MEDICINAL CHEMISTRY 18 16 5938 5944 scie scopus 000280664100017 2-s2.0-77955471833 Biochemistry & Molecular Biology Chemistry, Medicinal Chemistry, Organic Biochemistry & Molecular Biology Pharmacology & Pharmacy Chemistry Article CA2+ CHANNELS PAIN RAT MIBEFRADIL ALLODYNIA BLOCKERS MODEL T-type calcium channel blocker Diphenylpiperazine Formalin test Neuropathic pain