Yoo, Ji-Hye Lee, Hee Ju Kang, Kyungsu Jho, Eun Hye Kim, Chul Young Baturen, Dulamjav Tunsag, Jigjidsuren Nho, Chu Won 2024-01-20T19:00:23Z 2024-01-20T19:00:23Z 2021-09-05 2010-08 0278-6915 https://pubs.kist.re.kr/handle/201004/131209 As aberrant activation of Wnt/beta-catenin signaling is one of the major mechanisms of carcinogenesis in colon cancer, identification of inhibitors of this pathway may aid in colon cancer prevention. We investigated the ability of the lignans arctiin, matairesinol and arctigenin from Saussurea salicifolia to inhibit Wnt/beta-catenin signaling in SW480 human colon cancer cells. The lignans inhibited SW480 cell growth. In addition, the transcriptional activity of a reporter construct containing the TCF binding element (TBE) was decreased after the treatment with all three lignans. Although arctiin, matairesinol and arctigenin have similar structures, arctigenin affected Wnt/beta-catenin signaling most significantly. Further, arctigenin reduced the level of beta-catenin by inducing its phosphorylation and thus its degradation. Arctigenin also decreased expression of the beta-catenin/TCF downstream genes CCND1, survivin and CTNNB1, and induced apoptosis. These results suggest that arctigenin, an aglycone with a methoxyl group, potently inhibits the growth of human colon cancer cells via the Wnt/beta-catenin signaling pathway. (C) 2010 Published by Elsevier Ltd. English PERGAMON-ELSEVIER SCIENCE LTD Lignans inhibit cell growth via regulation of Wnt/beta-catenin signaling Article 10.1016/j.fct.2010.05.056 1 FOOD AND CHEMICAL TOXICOLOGY, v.48, no.8-9, pp.2247 - 2252 FOOD AND CHEMICAL TOXICOLOGY 48 8-9 2247 2252 N scie scopus 000280991100036 2-s2.0-77955050681 Food Science & Technology Toxicology Food Science & Technology Toxicology Article COLORECTAL-CANCER PREVENTION INDUCE APOPTOSIS TUMOR-CELLS CYCLIN D1 OLIVE OIL RISK THERAPEUTICS ANTIOXIDANT DERIVATIVES ACTIVATION Lignans Arctigenin Arctiin Matairesinol Wnt/beta-catenin signaling Colon cancer