Oh, Sangtae Shin, Woon-Seob Ham, Jungyeob Lee, Seokjoon 2024-01-20T19:01:17Z 2024-01-20T19:01:17Z 2021-09-05 2010-07-15 0960-894X https://pubs.kist.re.kr/handle/201004/131253 A diastereomeric and regioisomeric library of 10-substituted triazolyl artemisinin compounds (6a-6h, 7a-7h, and 8a-8h) with a potent growth inhibitory activities against various cancer cell lines was established. These compounds were synthesized by a reaction with dihydroartemisinin (2) and various substituted triazoles (5a-5h) in methylene chloride using a BF(3)Et(2)O catalyst. Most of the compounds exhibited a strong potency in the submicromolar range, and, in particular, 6f, 7f, and 8f, which have a pentylphenyltriazole moiety, proved to be promising candidates for preclinical trials. (C) 2010 Elsevier Ltd. All rights reserved. English Pergamon Press Ltd. SOLUBLE DIHYDROARTEMISININ DERIVATIVES ANTIMALARIAL ACTIVITY DIFLUOROMETHYLENE KETONES ARTEETHER TOXICITY DRUG Acid-catalyzed synthesis of 10-substituted triazolyl artemisinins and their growth inhibitory activity against various cancer cells Article 10.1016/j.bmcl.2010.05.074 1 Bioorganic & Medicinal Chemistry Letters, v.20, no.14, pp.4112 - 4115 Bioorganic & Medicinal Chemistry Letters 20 14 4112 4115 scie scopus 000279258800027 2-s2.0-77953913247 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article SOLUBLE DIHYDROARTEMISININ DERIVATIVES ANTIMALARIAL ACTIVITY DIFLUOROMETHYLENE KETONES ARTEETHER TOXICITY DRUG Artemisinin Triazoyl artemisinin Anticancer Diastereomer Regioisomer