Oh, Sangtae Park, Byong-Gon Ham, Jungyeob Lee, Seokjoon 2024-01-20T19:01:21Z 2024-01-20T19:01:21Z 2021-09-04 2010-07-15 0960-894X https://pubs.kist.re.kr/handle/201004/131256 We have synthesized novel vasodilatation farnesylacetones 1 and 2, which are major active constituents of Sargassum siliquastrum collected from the coast of the East Sea in Korea, in 9 steps. A test of the vasodilatation effect of synthetic intermediates and their deprotected compounds on the basilar arteries of rabbits revealed that 14 and 14-1 have a similar dilation effect as their target marine natural products 1 and 2. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved. English Pergamon Press Ltd. NATURAL-PRODUCTS ALZHEIMERS-DISEASE DERIVATIVES ANTITUMOR DRUGS Synthesis of two marine farnesylacetones that dilate the basilar arteries of rabbits Article 10.1016/j.bmcl.2010.05.044 1 Bioorganic & Medicinal Chemistry Letters, v.20, no.14, pp.4206 - 4209 Bioorganic & Medicinal Chemistry Letters 20 14 4206 4209 scie scopus 000279258800048 2-s2.0-77953870731 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article NATURAL-PRODUCTS ALZHEIMERS-DISEASE DERIVATIVES ANTITUMOR DRUGS Farnesylacetones Vasodilatation Marine natural product Organic synthesis