Potta, Thrimoorthy Chun, ChangJu Song, Soo-Chang 2024-01-20T19:01:26Z 2024-01-20T19:01:26Z 2021-09-05 2010-07-12 1525-7797 https://pubs.kist.re.kr/handle/201004/131260 Photo-cross-linkable, functionalized, and thermosensitive polyphosphazenes were synthesized to develop a dual cross-linking system with properties of mechanically suitable strength and controllable biodegradation for injectable biomedical applications. The aqueous solutions of the polymers exhibited sol gel transition behaviors against temperature. The incorporated methacrylate groups were photo-cross-linked upon UV light under mild conditions, which resulted in the formation of compact three-dimensional networks. The thermoresponsive hydrophobic interactions at body temperature facilitated the rapid dual cross-linking accomplishment of the photo-cross-linking even under mild conditions. The characteristics of the polymers such as pore size and density showed that the inner three-dimensional networks depended on the degree of cross-linking of methacrylate units. Mechanical properties of the eel were also improved several folds after developing the photo-cross-linking in the network from the in vivo degradation studies. The results demonstrate that the photo-cross-linkable and thermoresponsive polyphosphazenes have great potential as injectable, biodegradable, and controllable carriers for various biomedical applications by tuning the mechanical gel property and the degradation rate. English AMER CHEMICAL SOC DRUG-DELIVERY CYTOCOMPATIBILITY POLYMERIZATION DEGRADATION SCAFFOLDS NETWORKS RELEASE CELLS GEL Dual Cross-Linking Systems of Functionally Photo-Cross-Linkable and Thermoresponsive Polyphosphazene Hydrogels for Biomedical Applications Article 10.1021/bm100197y 1 BIOMACROMOLECULES, v.11, no.7, pp.1741 - 1753 BIOMACROMOLECULES 11 7 1741 1753 scie scopus 000279679300008 2-s2.0-77955161124 Biochemistry & Molecular Biology Chemistry, Organic Polymer Science Biochemistry & Molecular Biology Chemistry Polymer Science Article DRUG-DELIVERY CYTOCOMPATIBILITY POLYMERIZATION DEGRADATION SCAFFOLDS NETWORKS RELEASE CELLS GEL