Kim, Eun-A Hahn, Hoh-Gyu Kim, Tae Ue Choi, Soo Young Cho, Sung-Woo 2024-01-20T19:02:36Z 2024-01-20T19:02:36Z 2021-09-02 2010-06-30 1976-6696 https://pubs.kist.re.kr/handle/201004/131317 Beta-Amyloid (A beta)-induced neuroinflammation is one of the key events in the development of neurodegenerative disease. We previously reported that KHG21834, a benzothiazole derivative, attenuates A beta-induced degeneration of cortical and mesencephalic neurons in vitro. In the present work, we show that KHG21834 reduces A beta-mediated neuroinflammation in brain. In vivo intracerebroventricular infusion of KHG21834 leads to decreases in the numbers of activated astrocytes and microglia and level of proinflammatory cytokines such as interleukin-1 beta and tumor necrosis factor-alpha induced by A beta in the hippocampus. This suppression of neuroinflammation is associated with decreased neuron loss, restoration of synaptic dysfunction biomarkers in the hippocampus to control level, and diminished amyloid deposition. These results may suggest the potential therapeutic efficacy of KHG21834 for the treatment of A beta-mediated neuroinflammation. [BMB reports 2010; 43(6): 413-418] English KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY NITRIC-OXIDE SYNTHASE SIGNAL-REGULATED KINASE ALZHEIMERS-DISEASE MESENCEPHALIC NEURONS MICROGLIAL ACTIVATION INDUCED NEUROTOXICITY DOPAMINERGIC-NEURONS PC12 CELLS EXPRESSION LIPOPOLYSACCHARIDE Attenuation of beta-amyloid-induced neuroinflammation by KHG21834 in vivo Article 10.5483/BMBRep.2010.43.6.413 1 BMB REPORTS, v.43, no.6, pp.413 - 418 BMB REPORTS 43 6 413 418 scie scopus kci ART001451922 000279380000005 2-s2.0-77955836320 Biochemistry & Molecular Biology Biochemistry & Molecular Biology Article NITRIC-OXIDE SYNTHASE SIGNAL-REGULATED KINASE ALZHEIMERS-DISEASE MESENCEPHALIC NEURONS MICROGLIAL ACTIVATION INDUCED NEUROTOXICITY DOPAMINERGIC-NEURONS PC12 CELLS EXPRESSION LIPOPOLYSACCHARIDE Alzheimer&apos s disease Beta-amyloid KHG21834 Microglia Neuroinflammation