Song, Mee Kim, Youn Jung Lee, Ji-Na Ryu, Jae Chun 2024-01-20T19:02:44Z 2024-01-20T19:02:44Z 2021-09-02 2010-06-20 1976-0280 https://pubs.kist.re.kr/handle/201004/131323 Environmental chemicals have attracted attention owing to their effects on thyroid functions, because thyroid hormones (THs) play key roles in the development of mammalian organs such as the brain and heart. Carbaryl, which is used as an insecticide, is a cholinesterase inhibitor and is toxic to humans. It is classified as a likely human carcinogen by the United States Environmental Protection Agency (EPA). It induces thyroid dysfunction by acting as a thyroid receptor (TR) antagonist and altering the circulating levels of THs; it increases triiodothryonine (13) levels. Vinclozolin is a fungicide and is known as an endocrine disruptor. Vinclozolin decreases circulating thyroxine (T-4) levels and increases thyroid stimulating hormone (TSH) levels. We examined the changes in gene expression profiles in human thyroid follicular carcinoma FTC-238 cells that were exposed to carbaryl and vinclozolin and various chemicals by using a human oligonucleotide chip. Several genes altered by carbaryl and vinclozolin belonged to the gene ontology (GO) categories of cell cycle, apoptosis, development, and metabolism. Further, we identified 106 classifiers represent in the contrast the reaction in thyroid systems by carbaryl and vinclozolin. These classifiers are potential biomarkers of the final symptoms (i.e., hyperthyroidism and hypothyroidism) that result from disruption of THs production. In conclusion, our study suggests potential biomarkers and biological functions related to thyroid dysfunction and biological functions to be investigated in response to the exposure of environmental chemicals such as carbaryl and vinclozolin. English KOREAN BIOCHIP SOCIETY-KBCS CARBOHYDRATE-METABOLISM MEDIATED APOPTOSIS HORMONE HYPERTHYROIDISM GENES MICROARRAY TOXICITY PATHWAY FAS Genome-wide expression profiling of carbaryl and vinclozolin in human thyroid follicular carcinoma (FTC-238) cells Article 10.1007/s13206-010-4201-1 1 BIOCHIP JOURNAL, v.4, no.2, pp.89 - 98 BIOCHIP JOURNAL 4 2 89 98 scie scopus kci other ART001451545 000279007800001 2-s2.0-79953065771 Biochemical Research Methods Chemistry, Analytical Nanoscience & Nanotechnology Biochemistry & Molecular Biology Chemistry Science & Technology - Other Topics Article CARBOHYDRATE-METABOLISM MEDIATED APOPTOSIS HORMONE HYPERTHYROIDISM GENES MICROARRAY TOXICITY PATHWAY FAS Carbaryl Vinclozolin Thyroid Microarray Gene ontology (GO)