Chung, Sangwon Ingle, Nilesh P. Montero, Gerardo A. Kim, Soo Hyun King, Martin W. 2024-01-20T19:04:36Z 2024-01-20T19:04:36Z 2021-09-02 2010-06 1742-7061 https://pubs.kist.re.kr/handle/201004/131416 Current surgical therapy for diseased vessels less than 6 mm in diameter involves bypass grafting with autologous arteries or veins. Although this surgical practice is common, it has significant limitations and complications, such as occlusion, intimal hyperplasia and compliance mismatch. As a result, cardiovascular biomaterials research has been motivated to develop tissue-engineered blood vessel substitutes. In this study, vascular tissue engineering scaffolds were fabricated using two different approaches, namely melt spinning and electrospinning. Small diameter tubes were fabricated from an elastomeric bioresorbable 50:50 poly(L-lactide-co-epsilon-caprolactone) copolymer having dimensions of 5 mm in diameter and porosity of over 75%. Scaffolds electrospun from two different solvents, acetone and 1,1,1,3,3,3-hexafluoro-2-propanol were compared in terms of their morphology, mechanical properties and cell viability. Overall, the mechanical properties of the prototype tubes exceeded the transverse tensile values of natural arteries of similar caliber. In addition to spinning the polymer separately into melt-spun and electrospun constructs, the approach in this study has successfully demonstrated that these two techniques can be combined to produce double-layered tubular scaffolds containing both melt-spun macrofibers (<200 mu m in diameter) and electrospun submicron fibers (>400 nm in diameter). Since the vascular wall has a complex multilayered architecture and unique mechanical properties, there remain several significant challenges before a successful tissue-engineered artery is achieved. (C) 2010 Published by Elsevier Ltd. on behalf of Acta Materialia Inc. English ELSEVIER SCI LTD OF-THE-ART SMOOTH-MUSCLE BLOOD-VESSEL EXTRACELLULAR-MATRIX NANO-FIBER NANOFIBERS DESIGN CELL FABRICATION COPOLYMERS Bioresorbable elastomeric vascular tissue engineering scaffolds via melt spinning and electrospinning Article 10.1016/j.actbio.2009.12.007 1 ACTA BIOMATERIALIA, v.6, no.6, pp.1958 - 1967 ACTA BIOMATERIALIA 6 6 1958 1967 scie scopus 000278250100009 2-s2.0-77956622419 Engineering, Biomedical Materials Science, Biomaterials Engineering Materials Science Article OF-THE-ART SMOOTH-MUSCLE BLOOD-VESSEL EXTRACELLULAR-MATRIX NANO-FIBER NANOFIBERS DESIGN CELL FABRICATION COPOLYMERS Tissue engineering scaffolds Elastomeric PLCL Melt spinning Electrospinning