Cho, Yong Woo Choi, Minyoung Lee, Kyunghae Song, Soo-Chang 2024-01-20T19:30:50Z 2024-01-20T19:30:50Z 2021-09-02 2010-05 0883-9115 https://pubs.kist.re.kr/handle/201004/131480 An intelligent drug delivery system that exhibits a thermosensitive phase transition from a soluble to insoluble state was developed to deliver drugs into a tumor. Cyclotriphosphazene-Pt-DACH (trans(+/-)-1,2-diaminocyclohexane) conjugates with dipeptide spacers were synthesized by successive reaction steps. The conjugates exhibited a reversible and thermosensitive phase transition with lower critical solution temperature in aqueous media that was varied by the substitution of different hydrophilic/hydrophobic side groups. The conjugate had similar cytotoxicity as cisplatin, but much greater than carboplatin against various human cancer cell lines. The conjugate was much more potent than cisplatin against the cisplatin-resistant cell line, A2780/CP70. The biodistribution and pharmacokinetic studies indicate that the present thermosensitive conjugate exhibits locally controlled drug delivery feature that could circumvent surgery treatment and reduce toxic side effects due to systemic administration. English SAGE PUBLICATIONS LTD AMINO-ACID ESTERS BIODEGRADABLE THERMOSENSITIVE POLYMERS ANTITUMOR-ACTIVITY POLY(ETHYLENE GLYCOL) SIDE-GROUPS CONTROLLED-RELEASE CELL-LINES HYDROGELS DOXORUBICIN COMPLEXES Cyclotriphosphazene-Pt-DACH Conjugates with Dipeptide Spacers for Drug Delivery Systems Article 10.1177/0883911509356377 1 JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, v.25, no.3, pp.274 - 291 JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS 25 3 274 291 scie scopus 000277323300004 2-s2.0-77952254042 Biotechnology & Applied Microbiology Materials Science, Biomaterials Polymer Science Biotechnology & Applied Microbiology Materials Science Polymer Science Article AMINO-ACID ESTERS BIODEGRADABLE THERMOSENSITIVE POLYMERS ANTITUMOR-ACTIVITY POLY(ETHYLENE GLYCOL) SIDE-GROUPS CONTROLLED-RELEASE CELL-LINES HYDROGELS DOXORUBICIN COMPLEXES cyclotriphosphazene DACH thermosensitive LCST biodistribution