Jung, Sang-Yong Kim, Juhyun Kwon, Oh Bin Jung, Jung Hoon An, Kyongman Jeong, A. Young Lee, C. Justin Choi, Yun-Beom Bailey, Craig H. Kandel, Eric R. Kim, Joung-Hun 2024-01-20T19:34:04Z 2024-01-20T19:34:04Z 2021-09-02 2010-03-09 0027-8424 https://pubs.kist.re.kr/handle/201004/131635 Despite considerable evidence for a critical role of neuroligin-1 in the specification of excitatory synapses, the cellular mechanisms and physiological roles of neuroligin-1 in mature neural circuits are poorly understood. In mutant mice deficient in neuroligin-1, or adult rats in which neuroligin-1 was depleted, we have found that neuroligin-1 stabilizes the NMDA receptors residing in the post-synaptic membrane of amygdala principal neurons, which allows for a normal range of NMDA receptor-mediated synaptic transmission. We observed marked decreases in NMDA receptor-mediated synaptic currents at afferent inputs to the amygdala of neuroligin-1 knockout mice. However, the knockout mice exhibited a significant impairment in spike-timing-dependent long-term potentiation (STD-LTP) at the thalamic but not the cortical inputs to the amygdala. Subsequent electrophysiological analyses indicated that STD-LTP in the cortical pathway is largely independent of activation of postsynaptic NMDA receptors. These findings suggest that neuroligin-1 can modulate, in a pathway-specific manner, synaptic plasticity in the amygdala circuits of adult animals, likely by regulating the abundance of postsynaptic NMDA receptors. English NATL ACAD SCIENCES TIMING-DEPENDENT PLASTICITY LATERAL AMYGDALA FEAR AUTISM TRAFFICKING SYNAPSES EXPRESSION CIRCUITS BRAIN NLGN4 Input-specific synaptic plasticity in the amygdala is regulated by neuroligin-1 via postsynaptic NMDA receptors Article 10.1073/pnas.1001084107 1 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.107, no.10, pp.4710 - 4715 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107 10 4710 4715 scie scopus 000275368400041 2-s2.0-77949538687 Multidisciplinary Sciences Science & Technology - Other Topics Article TIMING-DEPENDENT PLASTICITY LATERAL AMYGDALA FEAR AUTISM TRAFFICKING SYNAPSES EXPRESSION CIRCUITS BRAIN NLGN4 STD-LTP thalamic pathway cortical pathway autism