이준상 유경호 2024-01-20T19:34:31Z 2024-01-20T19:34:31Z 2021-09-06 2010-03 1225-9098 https://pubs.kist.re.kr/handle/201004/131657 Melanoma is the most aggressive form of skin cancer and is the fastest growing type of cancer in the United States. We report here the synthesis of a novel series of quinazolinylmethoxybenzene derivatives 1a-c and their antiproliferative activities against A375human melanoma cell line. Among them, urea compound 1a (IC50 = 4.8 μM) having 4-chloro-3-trifluoromethylphenyl moiety showed superior antiproliferative activity to Sorafenib (IC50 = 5.5 μM) as a reference compound. These results will helpful for designing structure of a therapeutic agent for the treatment of melanoma. Korean 한국응용과학기술학회 Quinazolinylmethoxybenzene 유도체 합성 및 흑색종 세포증식 저해효능 Synthesis and Antiproliferative Activity of Quinazolinylmethoxybenzene Derivatives against Melanoma Cell Line Article 2 한국응용과학기술학회지, v.27, no.1, pp.20 - 28 한국응용과학기술학회지 27 1 20 28 kci ART001437205 quinazolinylmethoxybenzenes synthesis antiproliferative activity melanoma cell line