Kim, Dong Min Lee, Bong Soo Park, Cheol Ho Park, Kwideok Son, Tae-Il Jeong, Myeong Ho Han, Dong Keun 2024-01-20T19:35:08Z 2024-01-20T19:35:08Z 2021-09-02 2010-03 0379-153X https://pubs.kist.re.kr/handle/201004/131688 Medical metal stents inserted to patients with a cardiovascular disease associated with coronary artery system have relatively increased the survival rate. The development of new stems is, however, urgently required due to restenosis and late thrombosis generated in metal stents. To solve these problems. the biodegradable polymers such as poly(lactide-co-glycolide) (PLGA), poly (L lactide) (PLLA), and poly (epsilon-caprolactone) (PCL) were mixed with alpha lipoic acid (ALA). which is well known to inhibit the proliferation of neointimal hyperplasia. Subsequently. the ALA loaded polymers were coated on stainless steel by electrospray. The drug-eluting behaviors from the coated polymers were investigated according to kinds and concentrations of polymers. spray rates, and kinds of solvents. The drug eluting rate from PCL with the lowest glass transition temperature was the fastest among three polymers and followed by PLGA and PLLA. The surface roughness increased as the spray rate was increased and also the drug eluting rate was affected by kinds of solvents with different boiling point. it is expected that drug eluting stem (DES) coated with ALA loaded polymers can be applied practically for clinical applications by controlling the behavior of drug release. Korean POLYMER SOC KOREA CORONARY RESTENOSIS FILM Metal Surface Coating Using Electrospray of Biodegradable Polymers and alpha-Lipoic Acid Release Behavior for Drug-Eluting Stents Article 10.7317/pk.2010.34.2.178 1 POLYMER-KOREA, v.34, no.2, pp.178 - 183 POLYMER-KOREA 34 2 178 183 scie scopus kci ART001429444 000277718400015 2-s2.0-77952914032 Polymer Science Polymer Science Article CORONARY RESTENOSIS FILM coronary artery drug-eluting stent(DES) biodegradable polymers alpha lipoic acid electrospray coating