Jun, Yong Joo Park, Min Kyoung Jadhav, Vithal B. Song, Ju Hee Chae, Song Wha Lee, Hwa Jeong Park, Kyung Su Jeong, Byeongmoon Choy, Jin Ho Sohn, Youn Soo 2024-01-20T20:00:30Z 2024-01-20T20:00:30Z 2021-09-02 2010-02-25 0168-3659 https://pubs.kist.re.kr/handle/201004/131705 Cyclotriphosphazenes grafted with equimolar amounts of a hydrophilic polyethylene glycol and a hydrophobic oligopeptide in cis-nongeminal way form a new class of tripodal amphiphiles allowing both intra- and intermolecular hydrophobic interactions that differ from linear block copolymer amphiphiles. It has been found in this study that the tripodal amphiphiles can be tuned for self-assembly from micelles to bilayered polymersomes by controlling the hydrophobicity of the oligopeptide grafted. For instance, the tripodal amphiphiles with an intermediate hydrophobicity (O < log P < 1) (P = [solute](n-octanol)/[solute](water)) reassemble from initially formed micelles into polymersomes, whereas the trimers bearing highly hydrophobic oligopeptides (log P > 1) remain as stable micelles in aqueous solution. These biodegradable polymersomes exhibit outstanding physicochemical properties required for practical drug delivery and other biomedical applications. In particular, the cyclic phosphazene trimer platinated with a hydrophobic cis-bis (cyclohexylamine)Pt-moiety forms very stable polymersomes with excellent tumor selectivity by EPR effect and seems to be a promising candidate for preclinical studies. (C) 2009 Elsevier B.V. All rights reserved. English ELSEVIER MACROMOLECULAR THERAPEUTICS DRUG-DELIVERY MICELLES Tripodal amphiphiles tunable for self-assembly to polymersomes Article 10.1016/j.jconrel.2009.10.004 1 JOURNAL OF CONTROLLED RELEASE, v.142, no.1, pp.132 - 137 JOURNAL OF CONTROLLED RELEASE 142 1 132 137 scie scopus 000275586700017 2-s2.0-76749129588 Chemistry, Multidisciplinary Pharmacology & Pharmacy Chemistry Pharmacology & Pharmacy Article MACROMOLECULAR THERAPEUTICS DRUG-DELIVERY MICELLES Polymersome Micelle Amphiphile Cyclotriphosphazene Oligopeptide