Park, Daae Kim, Hyoung Ja Jung, Seo Yun Yook, Chang-Soo Jin, Changbae Lee, Yong Sup 2024-01-20T20:01:27Z 2024-01-20T20:01:27Z 2021-09-02 2010-02 0009-2363 https://pubs.kist.re.kr/handle/201004/131753 To search for secondary metabolites of Alnus hirsuta (Betulaceae), various chromatographic separations of the ethyl acetate soluble fraction of the stem bark of A. hirsuta led to the isolation of a new diarylheptanoid glycoside, (3R)-1,7-bis-(4-dihydroxyphenyl)-3-heptanol 3-O-beta-D-glucopyranosyl(1 -> 3)-beta-D-Xylopyranoside (13) and twelve diarylheptanoid derivatives, namely, oregonin (1), rubranoside A (2), hirsutanonol 5-O-beta-D-glucopyranoside (3), rubranoside B (4), rubranoside C (5), hirsutanonol (6), hirsutenone (7), (5S)-O-methylhirsutanonol (8), platyphylloside (9), platyphyllonol 5-O-beta-D-xylopyranoside (10), aceroside VII (11) and platypyllenone (12). Isolates were assessed for their hepatoprotective effects against tert-butylhydroperoxide (t-BHP)-induced toxicity in HepG2 cells. Of these isolates, compounds 1-8 showed significant hepato protective effects on t-BHP-induced damage to HepG2 cells, with 8 exhibiting the greatest protective effect (50.7 +/- 3.7% at a concentration of 10 mu m). English PHARMACEUTICAL SOC JAPAN ABSOLUTE-CONFIGURATION SILYBUM-MARIANUM FEMALE FLOWERS HEPATOCYTES CYTOTOXICITY CONSTITUENTS FLAVONOIDS JAPONICA (-)-CENTROLOBOL SERRULATOIDES A New Diarylheptanoid Glycoside from the Stem Bark of Alnus hirsuta and Protective Effects of Diarylheptanoid Derivatives in Human HepG2 Cells Article 10.1248/cpb.58.238 1 CHEMICAL & PHARMACEUTICAL BULLETIN, v.58, no.2, pp.238 - 241 CHEMICAL & PHARMACEUTICAL BULLETIN 58 2 238 241 scie scopus 000274007200019 2-s2.0-76149135714 Chemistry, Medicinal Chemistry, Multidisciplinary Pharmacology & Pharmacy Pharmacology & Pharmacy Chemistry Article ABSOLUTE-CONFIGURATION SILYBUM-MARIANUM FEMALE FLOWERS HEPATOCYTES CYTOTOXICITY CONSTITUENTS FLAVONOIDS JAPONICA (-)-CENTROLOBOL SERRULATOIDES Alnus hirsuta diarylheptanoid derivative hepatoprotective effect tert-butylhydroperoxide HepG2 cell