Lim, Chang-Keun Kim, Sehoon Kwon, Ick Chan Ahn, Cheol-Hee Park, Soo Young 2024-01-20T20:03:45Z 2024-01-20T20:03:45Z 2021-09-01 2009-12-22 0897-4756 https://pubs.kist.re.kr/handle/201004/131864 Novel fluorescent bionanoparticles (GC3CNx) were prepared by self-assembly of biopolymeric amphiphiles that are composed of hydrophilic glycol chitosan (GC) as a biopolymeric backbone and a dipolar tricyanostilbene derivative (3CN) as a densely conjugated hydrophobic pendant. In the molecular design of 3CN, a dipolar electronic structure was introduced to spectrally shift the aggregation-induced enhanced fluorescence of the a-cyanostilbene skeleton toward the near-infrared (NIR) useful for bioimaging. It has been Found that the fluorescence of GC3CNx nanoparticles is red-shifted and intensified by increasing the 3CN content in the biopolymeric amphiphile. By cellular and in vivo imaging experiments, we demonstrate that GC3CNx nanoparticles have great potential for NIR bioimaging, with attractive properties including enhanced fluorescence signal, efficient cellular uptake, and better spectral coincidence with the in vivo transparent window. English AMER CHEMICAL SOC GLYCOL CHITOSAN NANOPARTICLES MODIFIED SILICA NANOPARTICLES ORGANIC NANOPARTICLES ENHANCED FLUORESCENCE EMISSION THERAPY Dye-Condensed Biopolymeric Hybrids: Chromophoric Aggregation and Self-Assembly toward Fluorescent Bionanoparticles for Near Infrared Bioimaging Article 10.1021/cm902379x 1 CHEMISTRY OF MATERIALS, v.21, no.24, pp.5819 - 5825 CHEMISTRY OF MATERIALS 21 24 5819 5825 scie scopus 000272597500016 2-s2.0-72949110425 Chemistry, Physical Materials Science, Multidisciplinary Chemistry Materials Science Article GLYCOL CHITOSAN NANOPARTICLES MODIFIED SILICA NANOPARTICLES ORGANIC NANOPARTICLES ENHANCED FLUORESCENCE EMISSION THERAPY