이기세 이성호 조영창 윤구 천승훈 강복윤 2024-01-20T20:04:41Z 2024-01-20T20:04:41Z 2021-09-06 2009-12 0377-9556 https://pubs.kist.re.kr/handle/201004/131908 Licochalcone A is a chalcone isolated from the roots of Glycyrrhiza inflate. In this study, we examined the effects of licochalonce A on the production of cytokines in LPS-activated macrophages. Licochalcone A inhibited the secretion of proinflammatory cytokines such as IL-1β, IL-6, and TNF-α. The reduced secretion of proinflammatory cytokines is related to the differences in the mRNA expression of IL-1β, IL-6, and TNF-α. Moreover, licochalcone A inhibited the mRNA expression of IL-12p40, IL-18, and IL-23p19. To investigate its mechanism, we performed gel shift assay. Licochalcone A reduced nuclear NF-κB binding activity in LPS-activated RAW264.7 cells. Taken together, these results suggest that licochalcone A has anti-inflammatory effects in LPS-activated macrophages and its mechanism could be through the down-regulation of binding to the κB site. Korean 대한약학회 Licochalcone A가 대식세포주의 사이토카인 생성에 미치는 영향 Effect of Licochalcone A on the Production of Cytokines in LPS-Activated RAW264.7 Macrophage Cells Article 2 약 학 회 지, v.53, no.6, pp.321 - 327 약 학 회 지 53 6 321 327 kci ART001413499 licochalcone A macrophage inflammation cytokines