Lee, Joo Young Song, Dae-Geun Lee, Eun Ha Jung, Sang Hoon Nho, Chu Won Cha, Kwang Hyun Pan, Cheol-Ho 2024-01-20T20:04:59Z 2024-01-20T20:04:59Z 2021-09-05 2009-12 1738-2203 https://pubs.kist.re.kr/handle/201004/131923 AKR1B10 is a human NADPH-dependent aldo-keto reductase family 1 1310, which has been considered as a potential cancer therapeutic target. 3,5-O-Dicaffeoyl-epi-quinic acid (3,5-DCQA) was isolated from ethyl acetate fraction of Gymnaster koraiensis (Nakai) Kitam as an AKR1B10 inhibitor. 3,5-DCQA inhibited the activity of recombinant human AKR1B10 (rhAKR1B10) with its IC50 value of 1.2 mu M and its inhibition mode was uncompetitive from enzyme kinetic analysis. English KOREAN SOC APPLIED BIOLOGICAL CHEMISTRY KETO REDUCTASE FAMILY-1 B10 MEMBER Inhibitory Effects of 3,5-O-Dicaffeoyl-epi-quinic Acid from Gymnaster koraiensis on AKR1B10 Article 10.3839/jksabc.2009.121 1 JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY, v.52, no.6, pp.731 - 734 JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY 52 6 731 734 scie kci ART001412126 000274066900025 Food Science & Technology Food Science & Technology Article KETO REDUCTASE FAMILY-1 B10 MEMBER AKR1B10 aldose reductase-like anticancer 3,5-DCQA 3,5-O-dicaffeoyl-epi-quinic acid Gymnaster koraiensis