Lee, Seulki Ryu, Ju Hee Park, Kyeongsoon Lee, Aeju Lee, Seung-Young Youn, In-Chan Ahn, Cheol-Hee Yoon, Soon Man Myung, Seung-Jae Moon, Dae Hyuk Chen, Xiaoyuan Choi, Kuiwon Kwon, Ick Chan Kim, Kwangmeyung 2024-01-20T20:05:11Z 2024-01-20T20:05:11Z 2021-09-04 2009-12 1530-6984 https://pubs.kist.re.kr/handle/201004/131932 We report here a new protease activatable strategy based on a polymer nanoparticle platform. This nanosensor delivers chemically labeled matrix metalloproteinase (MMP)-activatable fluorogenic peptides to the specific MMPs of interest in vivo. Intravenous administration of the nanosensor in an MMP-positive SCC-7 xenograft tumor and a colon cancer mouse model verified the enzyme specificity of the nanosensor in vivo. The design platform of the nanosensor is flexible and can be fine-tuned for a wide array of applications such as the detection of biomarkers, early diagnosis of disease, and monitoring therapeutic efficacy. English AMER CHEMICAL SOC MATRIX METALLOPROTEINASES CANCER PROBES MECHANISM Polymeric Nanoparticle-Based Activatable Near-Infrared Nanosensor for Protease Determination In Vivo Article 10.1021/nl902709m 1 NANO LETTERS, v.9, no.12, pp.4412 - 4416 NANO LETTERS 9 12 4412 4416 scie scopus 000272395400078 2-s2.0-71949091979 Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Physics, Condensed Matter Chemistry Science & Technology - Other Topics Materials Science Physics Article MATRIX METALLOPROTEINASES CANCER PROBES MECHANISM