Kim, Seung Hwan Kumar, Ch. Naveen Kim, Hyoung Ja Kim, Dong Han Cho, Jungsook Jin, Changbae Lee, Yong Sup 2024-01-20T20:30:39Z 2024-01-20T20:30:39Z 2021-09-05 2009-11-01 0960-894X https://pubs.kist.re.kr/handle/201004/131963 Due to high reactivity, reactive oxygen species can attack biological molecules leading to cell or tissue injury. In this study, glucose moiety was attached at the C-7 position of quercetin 3-O-methyl ether (1) and luteolin (2) through glycosidic bond or ether linkage. The glucose-containing compounds showed potent DPPH and superoxide anion radical scavenging and lipid peroxidation inhibition activities and nearly equivalent protective actions to the parent aglycons against the H2O2-induced oxidative neuronal damage in primary cultured rat cortical cells. Among the compounds tested, 3b and 3c were the most potent (IC50 values = 7.33 and 5.34 mu M, respectively), exhibiting nearly equivalent actions to the parent compounds 1 and 2 (IC50 = 3.50 and 3.75 mu M, respectively). (C) 2009 Elsevier Ltd. All rights reserved. English Pergamon Press Ltd. INDICA VAR. SABOTEN LIPID-PEROXIDATION OXIDATIVE STRESS ABSORPTION SUPEROXIDE GLYCOSIDES CELLS STEMS SUGAR RATS Glucose-containing flavones-their synthesis and antioxidant and neuroprotective activities Article 10.1016/j.bmcl.2009.09.062 1 Bioorganic & Medicinal Chemistry Letters, v.19, no.21, pp.6009 - 6013 Bioorganic & Medicinal Chemistry Letters 19 21 6009 6013 scie scopus 000270561300005 2-s2.0-71749100898 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article INDICA VAR. SABOTEN LIPID-PEROXIDATION OXIDATIVE STRESS ABSORPTION SUPEROXIDE GLYCOSIDES CELLS STEMS SUGAR RATS Reactive oxygen species Antioxidant Ischemia Quercetin 3-O-methyl ether Glucose Neuroprotection