Bae, Hyun Jin Noh, Ji Heon Eun, Jung Woo Kim, Jeong Kyu Jung, Kwang Hwa Xie, Hong Jian Ahn, Young Min Ryu, Jae Chun Park, Won Sang Lee, Jung Young Nam, Suk Woo 2024-01-20T20:34:30Z 2024-01-20T20:34:30Z 2021-09-04 2009-09-30 1738-642X https://pubs.kist.re.kr/handle/201004/132150 Suppressors of cytokine signaling (SOCS) proteins were originally identified as negative feedback regulators of cytokine signaling and include the Janus kinase/Signal transducer and activator of transcription (JAK/STAT) pathways. Recent studies have shown that SOCS proteins negatively regulate the receptor tyrosine kinase (RTK) pathway including the insulin receptor (IR), EGFR, and KIT signaling pathways. In addition, SOCS1 and SOCS3 have been reported to have anti-tumor effects in human hepatocellular carcinoma (HCC). However, it is uncertain whether other members of the SOCS family are associated with tumor development and progression. In this study, to investigate whether SOCS6 is aberrantly regulated in HCC, we examined the expression level of SOCS6 in HCC by Western blot analysis and immunohistochemical staining. The results showed that SOCS6 was down-regulated in all examined HCCs compared to the corresponding normal tissues. In addition, expression of SOCS6 was observed in the cytoplasm of most normal and precancerous tissue, but not in the HCCs by immunohistochemical staining. This is first report to demonstrate that SOCS6 is aberrantly regulated in HCC. These findings suggest that underexpression of SOCS6 is involved in hepatocarcinogenesis, and SOCS6 may play a role, as a tumor suppressor, in HCC development and progression. English KOREAN SOCIETY TOXICOGENOMICS & TOXICOPROTEOMICS-KSTT PROTEASOMAL DEGRADATION NEGATIVE REGULATOR GROWTH-SUPPRESSION SOCS BOX JAK/STAT RECEPTOR PATHOGENESIS METHYLATION MUTATIONS RESPONSES Decreased Expression of the Suppressor of Cytokine Signaling 6 in Human Hepatocellular Carcinoma Article 1 MOLECULAR & CELLULAR TOXICOLOGY, v.5, no.3, pp.193 - 197 MOLECULAR & CELLULAR TOXICOLOGY 5 3 193 197 scie kci other 000270409100003 Biochemistry & Molecular Biology Toxicology Biochemistry & Molecular Biology Toxicology Article PROTEASOMAL DEGRADATION NEGATIVE REGULATOR GROWTH-SUPPRESSION SOCS BOX JAK/STAT RECEPTOR PATHOGENESIS METHYLATION MUTATIONS RESPONSES SOCS6 Down-regulation Hepatocellular carcinoma