Jin, Lan Hong, You-Chan Pyo, Jin-Woo Song, Hanwook Kang, Ji Yoon Lee, Sang Woo Yoon, Dae Sung Kim, Beop-Min No, Kwangsoo 2024-01-20T20:34:35Z 2024-01-20T20:34:35Z 2021-09-05 2009-09-20 1976-0280 https://pubs.kist.re.kr/handle/201004/132154 Calcium alginate beads are widely used in drug delivery studies due to their high biocompatibility and the simple gelatinization process. It is well known that the alginate bead size changes in solutions with time, increasing initially and decreasing at a later stage. Therefore, it is essential to monitor or predict the size change of the beads since it affects the drug delivery efficiency significantly. We used the optical tweezers, a non-contact method, to investigate the temporal changes of the alginate beads in solutions instead of using the traditional drying and weighing technique. Responses to alginate concentration or external stimuli such as pH were also studied. The power spectrum method was utilized to estimate the trapping forces on the beads, which is related to the particle size changes. The results of our experiment indicate that the optical tweezers technique can continuously monitor the swelling and degrading of an alginate bead in an aqueous medium over hours which poses a high potential for drug encapsulation and release efficiency studies in the future. English KOREAN BIOCHIP SOCIETY-KBCS SINGLE-MOLECULE PARTICLES DELIVERY CAPSULES RELEASE LATTICE SYSTEM CELLS MODEL TRAP Monitoring of Swelling and Degrading Behavior of Alginate Beads using Optical Tweezers Article 1 BIOCHIP JOURNAL, v.3, no.3, pp.213 - 218 BIOCHIP JOURNAL 3 3 213 218 scie scopus kci other ART001376649 000270028000005 2-s2.0-70350339681 Biochemical Research Methods Chemistry, Analytical Nanoscience & Nanotechnology Biochemistry & Molecular Biology Chemistry Science & Technology - Other Topics Article SINGLE-MOLECULE PARTICLES DELIVERY CAPSULES RELEASE LATTICE SYSTEM CELLS MODEL TRAP Swelling Degradation Alginate bead Optical tweezers Power spectral density