박철호 박귀덕 김재진 김영하 한동근 2024-01-20T20:35:13Z 2024-01-20T20:35:13Z 2021-09-06 2009-09 1226-4601 https://pubs.kist.re.kr/handle/201004/132184 Fibrin glue (FG) has been worldwidely used as a potent surgical adhesive for microvascular blood vessel anastomoses. It needs to improve some problems in present clinical uses by allowing a quicker clotting time and higher mechanical properties. The purpose of this study aims to engineer the novel fibrin glue/alginate (ALG) interpenetrating network (FG-ALG IPN) adhesive to achieve both requirements. The alginate networks in FG shorten the clotting time and enhance the mechanical properties. However, the incorporation of ampicillin (AMP) as antibiotics does not affect both clotting time and mechanical properties. As a consequence, this novel FG-ALG IPN is expected to be used for hemostasis, tissue adhesive, suture support, wound care, sealing and filling of body defect, drug carriers, and tissue-engineered scaffolds. Korean 한국생체재료학회 피브린 글루/알지네이트 상호 침투 구조체에 의한 지혈 및 기계적 물성 개선 Improvement of hemostasis and mechanical property by fibrin glue/alginate interpenetrating network Article 2 생체재료학회지, v.13, no.3, pp.113 - 116 생체재료학회지 13 3 113 116 kci ART001372382 Fibrin glue alginate interpenetrating network hemostasis mechanical property