Bae, H. J. Song, J. H. Noh, J. H. Kim, J. K. Jung, K. H. Eun, J. W. Xie, H. J. Ryu, J. C. Ahn, Y. M. Kim, S. Y. Lee, S. H. Yoo, N. J. Lee, J. Y. Park, W. S. Nam, S. W. 2024-01-20T21:02:50Z 2024-01-20T21:02:50Z 2021-09-03 2009-08 0028-2685 https://pubs.kist.re.kr/handle/201004/132288 EphA3 is a component of the Eph/ephrin tyrosine kinase system, which participates in vasculature development. This receptor/ligand system is associated with various signaling pathways related to cell growth and viability, cytoskeletal organization, cell migration, and anti-apoptosis. Accumulated evidence suggests that aberrant regulation of EphA3 and its genetic alterations are implicated in the development and progression of various cancers. However, despite a high incidence of EphA3 over-expression, no such investigation has been performed in hepatocellular carcinoma. Thus, we investigated genetic alterations of the EphA3 gene in 73 cases of hepatocellular carcinoma by single-strand conformational polymorphism and sequencing. One novel D219V missense mutation was found in the extracellular domain of EphA3, and two genetic alterations in the intracellular sterile-a-motif (SAM) domain of EphA3 appeared to be polymorphisms. Although the functional assessments of this mutant are incomplete, it is believed that this novel EphA3 mutation may contribute to the development of hepatocellular carcinoma. English AEPRESS SRO SOMATIC MUTATIONS CANCER CELLS EXPRESSION GENOMICS MELANOMA SCREEN FAMILY Low frequency mutation of the Ephrin receptor A3 gene in hepatocellular carcinoma Article 10.4149/neo_2009_04_331 1 NEOPLASMA, v.56, no.4, pp.331 - 334 NEOPLASMA 56 4 331 334 scie scopus 000271991100008 2-s2.0-68149142724 Oncology Oncology Article SOMATIC MUTATIONS CANCER CELLS EXPRESSION GENOMICS MELANOMA SCREEN FAMILY Eph receptor EphA3 hepatocellular carcinoma mutation