Nam, Bong Soo Kim, Hwan Oh, Chang-Hyun Lee, So Ha Cho, Seung Joo Sim, Tae Bo Hah, Jung-Mi Kim, Dong Jin Choi, Jung Hoon Yoo, Kyung Ho 2024-01-20T21:03:49Z 2024-01-20T21:03:49Z 2021-09-03 2009-07-01 0960-894X https://pubs.kist.re.kr/handle/201004/132325 The synthesis of a novel series of aminoquinoline derivatives 1a-p and their antiproliferative activities against A375 human melanoma cell line were described. Most compounds showed superior antiproliferative activities to Sorafenib as a reference compound. Among them, quinolinyloxymethylphenyl compounds 1k and 1l exhibited potent activities (IC50 = 0.77 and 0.79 mu M, respectively) and excellent selectivity against melanoma and fibroblast cell lines. (C) 2009 Elsevier Ltd. All rights reserved. English Pergamon Press Ltd. RANDOMIZED PHASE-III METASTATIC MELANOMA DACARBAZINE CHEMOTHERAPY CISPLATIN INTERLEUKIN-2 EXPERIENCE Aminoquinoline derivatives with antiproliferative activity against melanoma cell line Article 10.1016/j.bmcl.2009.05.007 1 Bioorganic & Medicinal Chemistry Letters, v.19, no.13, pp.3517 - 3520 Bioorganic & Medicinal Chemistry Letters 19 13 3517 3520 scie scopus 000266822800035 2-s2.0-66349104493 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article RANDOMIZED PHASE-III METASTATIC MELANOMA DACARBAZINE CHEMOTHERAPY CISPLATIN INTERLEUKIN-2 EXPERIENCE Aminoquinolines Antiproliferative activity Melanoma cell line Fibroblast cell line Selectivity