Shin, Hong-Sub Park, Kwideok Kim, Ji Heung Kim, Jae-Jin Han, Dong Keun Moon, Myoung-Woon Lee, Kwang-Ryeol Shin, Ji Hoon 2024-01-20T21:04:31Z 2024-01-20T21:04:31Z 2021-09-03 2009-07 0883-9115 https://pubs.kist.re.kr/handle/201004/132354 The surfaces of Nitinol (TiNi), a popular metal alloy for arterial stents were thin-coated with diamond-like carbon (DLC) and then grafted with poly(ethylene glycol) (PEG) to increase biocompatibility. The TiNi control, DLC-coated TiNi (TiNi-DLC), and the PEG-grafted TiNi-DLC (TiNi-DLC-PEG) surface characteristics and biocompatibility were evaluated. The hydrophilicity of the TiNi-DLC-PEG significantly increased and the amount of both oxygen and nitrogen on the TiNi-DLC-PEG also increased compared to the TiNi control and TiNi-DLC due to the grafted PEG. The ratio between albumin and fibrinogen was higher on the PEG-grafted surface than the other surfaces when tested with human blood components; the platelet adhesion decreased the most on the TiNi-DLC-PEG surface, indicating improved blood compatibility. For in vivo tests using a rat model, the samples that were implanted for 6 weeks formed fibrous tissue; the tissue layer was much thinner on the PEG-grafted sample than the other two groups. The present results indicate that PEG-grafted TiNi-DLC surface may be effective in enhancing biocompatibility of blood-contacting biomaterials including vascular stents. English SAGE PUBLICATIONS LTD ENHANCED BLOOD COMPATIBILITY SELF-ASSEMBLED MONOLAYERS STAINLESS-STEEL STENTS NEGATIVE CILIA CONCEPT POLY(ETHYLENE GLYCOL) PROTEIN ADSORPTION BIOMEDICAL APPLICATIONS IN-VIVO SURFACE PLASMA Biocompatible PEG Grafting on DLC-coated Nitinol Alloy for Vascular Stents Article 10.1177/0883911509104273 1 JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, v.24, no.4, pp.316 - 328 JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS 24 4 316 328 scie scopus 000267602900002 2-s2.0-68149125591 Biotechnology & Applied Microbiology Materials Science, Biomaterials Polymer Science Biotechnology & Applied Microbiology Materials Science Polymer Science Article ENHANCED BLOOD COMPATIBILITY SELF-ASSEMBLED MONOLAYERS STAINLESS-STEEL STENTS NEGATIVE CILIA CONCEPT POLY(ETHYLENE GLYCOL) PROTEIN ADSORPTION BIOMEDICAL APPLICATIONS IN-VIVO SURFACE PLASMA stent nitinol (TiNi alloy) surface modification diamond-like carbon (DLC) poly(ethylene glycol) (PEG) biocompatibility