Lee, E.H. Ham, J. Ahn, H.R. Kim, M.C. Kim, C.Y. Pan, C.-H. Um, B.H. Jung, S.H. 2024-01-20T21:05:05Z 2024-01-20T21:05:05Z 2021-09-02 2009-07 0253-3073 https://pubs.kist.re.kr/handle/201004/132379 We examined ethanol extracts prepared from the Korean marine algae belonging to the Sargassaceae family for their inhibitory effects on α-glucosidase activity and free radicals in vitro. Among five marine algae, the extracts of Sargassum yezoense were found to possess strongly α-glucosidase inhibition and free radicals scavenging activities. Two compounds were isolated via bioactivity guided isolation and tested for their effects on α-glucosidase, DPPH, ABTS+ and Photochem® analysis.Their chemical structures were elucidated by spectral analysis and direct comparison with authentic compounds; their structures were identified as sargaquinoic acid (1) and sargahydroquinoic acid (2). The inhibitory effects of compound 1 and 2 (IC50 value: 14.2 and 12.8 μM, respectively) on α-glucosidase were more potent that of deoxynojirimycin as a positive control (IC50 value: 18.0 μ M). All compounds displayed antioxidative activity which was measured by DPPH, ABTS+ and Photoche® apparatus. Korean 1 deoxynojirimycin alpha glucosidase plant extract sargahydroquinoic acid sargaquinoic acid Sargassum yezoense extract unclassified drug antioxidant activity article drug effect drug isolation drug potency drug structure enzyme inhibition IC 50 nonhuman oxidative stress Sargassum Sargassum yezoense structure analysis Inhibitory effects of the compounds isolated from Sargassum yezoense on α-glucosidase and oxidative stress Article 1 Korean Journal of Pharmacognosy, v.40, no.2, pp.150 - 154 Korean Journal of Pharmacognosy 40 2 150 154 scopus kci ART001361622 2-s2.0-76649134447 Article 1 deoxynojirimycin alpha glucosidase plant extract sargahydroquinoic acid sargaquinoic acid Sargassum yezoense extract unclassified drug antioxidant activity article drug effect drug isolation drug potency drug structure enzyme inhibition IC 50 nonhuman oxidative stress Sargassum Sargassum yezoense structure analysis α-glucosidase Antioxidative activities Sargahydroquinoic acid Sargaquinoic acid Sargassum yezoense