Oh, Kyung Taek Oh, Young Taik Oh, Nam-Muk Kim, Kwangmyung Lee, Don Haeng Lee, Eun Seong 2024-01-20T21:05:14Z 2024-01-20T21:05:14Z 2021-09-03 2009-06-22 0378-5173 https://pubs.kist.re.kr/handle/201004/132384 Novel pH-responsive flower-like micelles were developed to provide the mechanism for pH-triggered drug release from drug carriers. The micelles (particle size: similar to 165 nm; critical micelle concentration (CMC): similar to 4 mu g/ml), constructed from poly(N-epsilon-(3-diethylamino)propyl isothiocyanatO-L-lysine)-b-poly(ethylene glycol)-b-poly(L-lactide) [poly(DEAP-Lys)-b-PEG-b-PLLA], were designed to have a self-assembled flower-like arrangement consisting of two hydrophobic blocks [deprotonated poly(DEAP-Lys) block and PLLA block] and a petal-like hydrophilic PEG block at physiological pH. As the pH decreases to slightly acidic pH (<pH 7.0), as in tumor extracellular pH (pH(e)), the flower-like micelles undergo a change in the hydrophobicity of the micellar core. The protonation of poly(DEAP-Lys) changed the physical property of the polymer from hydrophobic to hydrophilic, resulting in disintegration of the micellar core. The co-presence of a pH-insensitive PLLA block in the micellar core affected the protonation of poly(DEAP-Lys), allowing the micelle to be stable at pH 7.0-7.4. In this study using doxorubicin (DOX) as the model drug, DOX release from the micelles accelerated in response to tumor pH(e). (C) 2009 Elsevier B.V. All rights reserved. English ELSEVIER SCIENCE BV TUMOR EXTRACELLULAR PH MACROMOLECULAR THERAPEUTICS MULTIDRUG-RESISTANCE CANCER DELIVERY NANOTECHNOLOGY PERMEABILITY DOXORUBICIN GLYCOL) OPPORTUNITIES A smart flower-like polymeric micelle for pH-triggered anticancer drug release Article 10.1016/j.ijpharm.2009.04.005 1 INTERNATIONAL JOURNAL OF PHARMACEUTICS, v.375, no.1-2, pp.163 - 169 INTERNATIONAL JOURNAL OF PHARMACEUTICS 375 1-2 163 169 scie scopus 000267505400023 2-s2.0-67349237152 Pharmacology & Pharmacy Pharmacology & Pharmacy Article TUMOR EXTRACELLULAR PH MACROMOLECULAR THERAPEUTICS MULTIDRUG-RESISTANCE CANCER DELIVERY NANOTECHNOLOGY PERMEABILITY DOXORUBICIN GLYCOL) OPPORTUNITIES pH-sensitive flower-like micelle 3-Diethylamino propyl isothiocyanato-L-lysine pH-dependent drug release Tumor targeting